COMPREHENSIVE SICKLE CELL DISEASE CENTER

我们建议建立一个综合性镰状细胞病中心， 其主要目标是：1）改善对患有 居住在杜克大学集水区的镰状细胞病 医学中心，2）镰状细胞病影响的临床研究 影响：a）大脑对葡萄糖的代谢，B）心肺功能，c） 髋关节无菌性坏死，3）发展和机构 为病人提供有关镰状细胞综合征的信息教育项目， 杂合子，家庭，医生，护士，其他卫生专业人员， 和整个社区。 这些信息教育项目将 与针对教育指导的镰状细胞筛查有关， 检测，并将交织在目前活跃的国家镰状细胞 计划和社区为基础的镰状细胞计划。 4)基础研究 镰状细胞病的科学问题，包括：a）表征 和血红蛋白基因型的影响，B）血红蛋白的变构效应物的研究 血红蛋白功能，3）HbS对离子红细胞膜的影响 运输，d）红细胞膜流动性的研究。 为了扩散 全国各地的相关方案，并获得投入， 社区，我们将与国家计划和两个积极的 以社区为基础的镰状细胞团体。 我们将全力配合其他 参与国家镰状细胞计划的综合中心。

We propose to establish a Comprehensive Sickle Cell Disease Center which will have as its major objectives: 1) Improved care for patients with sickle cell disease residing in the catchment area of Duke University Medical Center, 2) Clinical Research on the effects of sickle cell disease on: a) metabolism of glucose by the brain, b) cardiopulmonary function, c) aseptic necrosis of the hip, 3) Development and institution of information-education programs about sickle cell syndromes for patients, heterozygotes, families, physicians, nurses, other health professionals, and the community at large. These information-education programs will be linked to sickle cell screening directed at education guidance, and disease detection and will be interwoven in the presently active State Sickle Cell Program and community based Sickle Cell Programs. 4) Study of basic scientific problems in sickle cell disease including: a) characterization and influence of hemoglobin geneotype, b) study of allosteric effectors of hemoglobin function, 3) effects of HbS geleation on ionic red cell membrane transport, d) studies of red cell membrane fludity. In order to diffuse the relevant programs throughout the State and to obtain input from the community, we will work with the State Program and two active community-based Sickle Cell groups. We will cooperate fully with other Comprehensive Centers involved in the National Sickle Cell Program.