TOLERABILITY AND EFFECTIVENESS OF CPC111 IN SICKLE CELL ANEMIA

本研究的目的是评价该药的耐受性和 静脉注射二磷酸果糖治疗慢性阻塞性肺疾病的疗效观察 急性镰状细胞危机。FDP为细胞提供4摩尔的三磷酸腺苷 每一个经过厌氧代谢的葡萄糖分子。这是感觉到的 增加的可用能量将帮助红细胞抵抗 并因此缩短了痛苦危机的持续时间。这个 GCRC被要求每6小时注射一次研究药物或安慰剂 超过72小时。总共将有96名患者在4岁以上进行评估 学习中心。主要假设将集中在减轻疼痛上。 在第一次输液后24小时。这项研究正在进行中。没有 要在此时报告结果。

The purpose of this study is to evaluate the tolerability and effectiveness of intravenous fructose diphosphate (FDP) in patients in acute sickle cell crisis. FDP provides 4 moles of ATP to the cell for every molecule of glucose that is anaerobically metabolized. It is felt that the increased available energy will help the red blood cell resist sickling and as a result shorten the duration of the pain crisis. The GCRC is requested for infusions of the study drug or placebo every 6 hours over 72 hours. There will be a total of 96 patients evaluated over 4 study centers. The primary hypothesis will focus on the reduction of pain at 24 hours after the first infusion. The study is ongoing. There are no results to report at this time.