NUTRITION COORDINATING CENTER

这项提议的总体目标是设计出高质量的 营养协调中心(NCC)为 MDRD研究并支持该研究的主要目的是测试 假设营养变量，特别是饮食蛋白质 和磷，并与慢性肾脏的进展有关 疾病。为了实现这一目标，国家协调委员会将开展工作 与MDRD临床中心合作，数据 协调中心、其他中央单位和中央协调中心工作人员 美国国家糖尿病、消化和肾脏疾病研究所 以及医疗保健融资管理局。这个 建议的NCC的主要职责是：1)设计 营养评估、干预和随访方案。 2)设计和/或选择和完善下列措施 评估个别参与者的遵从性以及 随机研究组。3)开发合适的材料 用于评估、干预、跟踪、合规监测、 培训、认证和干预评估。4)设计和 对临床中心人员实施适当的培训 参与营养评估程序，以及营养 干预和后续活动。5)分析饮食数据并 为临床中心提供最大反馈的设计分析 关于随机分组中的遵从性模式。6)协助 制定监测营养充分性的程序。

The overall objective of this proposal is to design a high quality Nutrition Coordinating Center (NCC) which would serve the MDRD Study and support the major aim of that study to test hypothesis that nutritional variables, specifically dietary protein and phosphorus, and related to the progression of chronic renal disease. In order to fulfill this objective the NCC will work collaboratively with the MDRD clinical centers, the Data Coordinating Center, other central units, and the staffs of the National Institute of Diabetes and Digestive and Kidney Diseases as well as the Health Care Financing Administration. The primary responsibilities of the proposed NCC will be: 1) Design the protocol for nutrition assessment, intervention, and follow-up. 2) Design and/or selection and refinement of measures for estimating compliance in individual participants as well as the randomized study groups. 3) Develop the appropriate materials for assessment, intervention, follow-up, compliance monitoring, training, certification, and intervention evaluation. 4) Design and implement appropriate training for clinical center personnel involved with nutrition assessment procedures, and nutrition intervention and follow-up activities. 5) Analyze dietary data and design analyses to provide maximum feedback to clinical centers on compliance patterns within randomized groups. 6) Assist in the development of procedures for monitoring nutritional adequacy.