Food Security and Health for East Africa

东非粮食安全与健康

• 批准号: EP/T01525X/1
• 负责人: John Woollins
• 金额: $ 142.17万
• 依托单位: University of St Andrews
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FT01525X%2F1
• 关键词: Food; Security; Health; East; Africa

This "Food Security and Health for East Africa" GCRF GRTA proposal focuses on breaking the current vicious circle of poor sustenance and poor human health by tackling food security and health challenges as a single highly connected developmental issue. The context of our proposal is the interrelationship between people and their environments seen through the lenses of food security and health, with the specific objectives of:(i) improving the availability of staple food by producing new climate resilient and disease resistant potato varieties that can be grown in East Africa; (ii) reducing the incidence of human Schistosomiasis by using prawns (Macrobrachium Rosenbergii) to disrupt the infection cycle; and(iii) increasing diagnostic accuracy of tuberculosis (TB) and Chronic Obstructive Pulmonary Diseases including improving antibiotic stewardship in the treatment of these diseases. Nutrition boosts immunity making nourished people less susceptible to infection, and if infected, they have better treatment outcomes.

这项名为“东非粮食安全与健康”的GCRF GRTA提案侧重于通过将粮食安全和健康挑战作为一个高度相关的发展问题来解决，从而打破目前食物匮乏和人类健康状况不佳的恶性循环。我们建议的背景是从粮食安全和健康的角度看待人与环境之间的相互关系，具体目标是：(1)通过培育可在东非种植的适应气候变化和抗病的马铃薯新品种，改善主食的供应；(2)利用对虾(罗氏沼虾)干扰感染循环，减少人类血吸虫病的发病率；(3)提高对结核病和慢性阻塞性肺病的诊断准确率，包括改善治疗这些疾病的抗生素管理。营养增强免疫力，使营养不良的人不太容易感染，如果感染，他们会有更好的治疗结果。

项目成果

A practical approach to render tuberculosis samples safe for application of tuberculosis molecular bacterial load assay in clinical settings without a biosafety level 3 laboratory.

一种在没有生物安全 3 级实验室的临床环境中使结核样本安全用于结核分子细菌载量测定应用的实用方法。

• DOI: 10.1016/j.tube.2022.102275
• 发表时间: 2023
• 期刊: Tuberculosis (Edinburgh, Scotland)
• 作者: Mtafya B

Allelic variants of a potato HEAT SHOCK COGNATE 70 gene confer improved tuber yield under a wide range of environmental conditions.

• DOI: 10.1002/fes3.377
• 发表时间: 2023-01
• 期刊: Food and energy security
• 影响因子: 5

Use of a molecular bacterial load assay to distinguish between active TB and post-TB lung disease.

• DOI: 10.5588/ijtld.21.0459
• 发表时间: 2022-03-01
• 期刊: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
• 作者: Mbelele PM;Sabiiti W;Heysell SK;Sauli E;Mpolya EA;Mfinanga S;Gillespie SH;Addo KK;Kibiki G;Sloan DJ;Mpagama SG
• 通讯作者: Mpagama SG