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Homegrown solutions in Viet Nam: bringing C. asiatica compounds forward as candidates to treat liver cancer

越南本土解决方案：将 C. asiatica 化合物作为治疗肝癌的候选药物

基本信息

批准号：
EP/T020164/1
负责人：
Christopher Serpell
金额：
$ 77.89万
依托单位：
University of Kent
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2020
资助国家：
英国
起止时间：
2020 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FT020164%2F1
关键词：
Homegrown solutions Viet Nam bringing

项目摘要

Liver cancer is a critical problem in Viet Nam, killing 25 thousand Vietnamese individuals each year - more than any other cancer. The problem is especially acute in Viet Nam because of the convergence of overlapping risk factors: hepatitis B and C are prevalent; alcohol consumption is very high; dioxins persist in the environment stemming from the use of Agent Orange during the Viet Nam War; and cultural and economic factors mean that patients frequently present for modern medicine only at a very advanced stage, relying first on traditional herbal remedies. However, Viet Nam also presents unique opportunities. Its traditional medicine is largely empirical i.e. based on experience rather than philosophical convictions. There is therefore opportunity for the discovery of natural products with therapeutic efficacy, which could be developed as approved drugs in an informed way through chemistry and biology. Centella asiatica is a popular medicinal herb, and our Vietnamese partners have discovered that one of its natural products, madecassic acid, is active against liver cancer, with chemical derivatives showing further improved potential. In this project we will work on a number of fronts to bring madecassic acid derivatives forward as potential new therapeutics against liver cancer, which could be produced within Viet Nam. This involves optimisation of growth conditions for maximal madecassic acid production (using analytical chemistry), improvement of chemical extraction processes, broadening the range of chemical derivatives in hand, in-depth studies using chemical biology of the cellular effects of madecassic acid, and exploration of use of polymers to control the rate of release in the body. This work will be underlined and supported by networking activities with stakeholders (doctors, industrialists, farmers, policy makers) in Viet Nam, and survey work to assess attitudes of the population to medicines which cross over the traditional-modern divide.

在越南，肝癌是一个严重的问题，每年导致25000名越南人死亡--比任何其他癌症都多。这一问题在越南尤为严重，因为重叠的风险因素汇聚在一起：乙肝和丙型肝炎盛行；酒精消费量非常高；由于越南战争期间使用橙剂，环境中持续存在二恶英；文化和经济因素意味着，患者往往只在非常晚期才来接受现代药物治疗，首先依赖传统草药。然而，越南也提供了独特的机会。其传统医学在很大程度上是经验性的，即基于经验而不是哲学信念。因此，有机会发现具有治疗效果的天然产品，这些产品可以通过化学和生物以知情的方式开发为经批准的药物。积雪草是一种受欢迎的草药，我们的越南合作伙伴发现其天然产品之一马迪卡酸具有抗肝癌活性，化学衍生品显示出进一步改善的潜力。在这个项目中，我们将在多个方面开展工作，以推动马迪雅酸衍生物作为潜在的治疗肝癌的新疗法，这种疗法可以在越南生产。这包括优化生长条件以最大限度地生产Madecassic酸(使用分析化学)，改进化学提取工艺，扩大手头化学衍生物的范围，利用化学生物学深入研究Madecassic酸对细胞的影响，以及探索使用聚合物来控制体内的释放速度。这项工作将得到与越南利益攸关方(医生、工业家、农民、政策制定者)的联网活动的强调和支持，并将通过调查工作来评估民众对跨越传统与现代鸿沟的药物的态度。