DIETARY INTERVENTION IN CHILDREN WITH ELEVATED LDL-C

本研究的目的是检验其有效性、可行性和安全性。 青春期前高血压病儿童的饮食干预研究 低密度脂蛋白-胆固醇(LDL-C)水平。从以下推荐中招募的参与者 一个由儿科医生和心脏病专家组成的大型网络将随机 分配到普通护理组或特殊护理组评估低密度脂蛋白-C 对非药物营养干预的反应。基于 美国心脏协会的建议和美国国立卫生研究院共识 专家小组将指导参与者最大限度地减少总脂肪， 饱和脂肪和膳食胆固醇以及补偿性增加 复合碳水化合物和水溶性纤维。饮食模式将会 强调水果、蔬菜、全谷物、低脂乳制品和瘦肉 动物蛋白来源。将鼓励减少钠含量。此外, 参赛者将被建议定期进行有氧运动，并 达到理想的身高体重。营养状况会特别小心 通过生化、人体测量和饮食评估进行监测，以 促进正常生长发育，达到最佳摄入量 必需的营养素。还将对心理社会发展进行评估和 应对同龄人压力和其他障碍的策略 我们将介绍一个相对缺乏支持性的现代社会中的营养状况。 两组之间的低密度脂蛋白水平变化将从 到研究结束时的基线，以评估 干预。这些发现将有助于确定儿童是否会 有足够的临床反应，以降低他们在 大于90百分位数的血浆胆固醇分布曲线 到75%或更低。这项研究的结果将改善我们的 对运动的生理和行为影响的理解 降低儿童血脂水平的非药物干预。

The purpose of this study is to test the efficacy, feasibility and safety of dietary intervention in pre-adolescent children with elevated LDL-cholesterol (LDL-C) levels. Participants recruited from referrals from a large network of pediatricians and cardiologists will be randomly assigned to either the usual or special care group to evaluate LDL-C response to non-pharmacologic nutritional intervention. Based on the recommendations of the American Heart Association and the NIH Consensus Panel, participants will be guided toward maximum reduction in total fat, saturated fat and dietary cholesterol with compensatory increases in complex carbohydrate and water soluble fiber. The eating pattern will emphasize fruits, vegetables, whole grains, low fat dairy products and lean animal protein sources. Sodium reduction will be encouraged. In addition, participants will be advised to perform regular aerobic activity and to achieve ideal weight for height. Nutritional status will be carefully monitored through biochemical, anthropometric and dietary assessments, to promote normal growth and development and to achieve optimal intake of essential nutrients. Psychosocial development will also be evaluated and strategies for coping with peer pressure and other obstacles to optimal nutrition in a relatively unsupportive modern society will be presented. Changes in LDL-C levels will be compared between the two groups from baseline to the end of the study to evaluate the effectiveness of intervention. These findings will help to determine whether children will have a sufficient clinical response to reduce their percentile rank on the plasma cholesterol distribution curve from greater than the 90th percentile to the 75th percentile or lower. Findings from this study will improve our understanding of the physiologic and behavioral effects of non-pharmacologic intervention to lower elevated lipid levels in children.