CHANGING EATING PATTERNS TO MEET LOW FAT GOALS: DISC

(改编自申请人的摘要) 儿童饮食干预研究(DISC)是由NHLBI资助的临床研究 旨在测试饮食干预的有效性和安全性的试验 降低8-10岁青春期前儿童的血清胆固醇水平 低密度脂蛋白胆固醇水平升高。儿童被随机分为干预组 饮食中28%的能量来自总脂肪，不到8%来自饱和脂肪 脂肪，多不饱和脂肪高达9%，胆固醇低于75毫克/4200kJ 每天或日常护理。营养学家收集了三次24小时召回 对营养学数据系统进行培训和认证 协调中心。食物按饱和脂肪和胆固醇进行分类。 内容和分类为GO！哇哦！帮助购物和制作的食物 外出就餐时适当选择。对家庭进行了关于 可以选择的有助于实现研究目标的食物类型，但 出现了各种不同的个人适应。三年后，干预行动 小组将总脂肪和饱和脂肪的平均膳食摄入量从 从基线的34%降至28.6%，血清低密度脂蛋白明显低于平时 护理剂量为0.09 mmol/L(3.3 mg/dL，p=0.02)。这些数据说明了 饮食行为以达到目标营养水平，但量化 饮食模式、食物选择和烹饪技术的具体变化 需要比已有的更进一步的编程和数据分析 在这项研究中完成的。建议进行额外的食物类别分析，以 量化和比较群体内部和群体之间采用的具体食物选择。 通过利用Go！对阵哇！系统中收集的饮食数据 6000次召回将被配置为识别低脂和高脂食品的选择 在整个饮食模式中。这将有助于更好地理解 关于在DISC中自己选择的饮食变化 坚持饮食的儿童，记录营养充足的水平 并为未来提供潜在的洞察力 这一年龄段关于减脂饮食的翻译研究。

(Adapted from the applicant's abstract) The Dietary Intervention Study in Children (DISC) is an NHLBI-funded clinical trial designed to test the efficacy and safety of a dietary intervention to reduce serum cholesterol levels in 8-10 year-old pre-pubertal children with elevated LDL cholesterol levels. Children were randomized to intervention with a diet that was 28% of energy from total fat, less than 8% from saturated fat, up to 9% from polyunsaturated fat and less than 75mg/4200kJ cholesterol per day or usual care. Three 24-hour recalls were collected by nutritionists trained and certified in the Nutrient Data System of the Nutrition Coordinating Center. Foods were ranked by saturated fat and cholesterol content and classified as GO! and WHOA! foods to help with shopping and making appropriate choices when eating out. Families were educated regarding the types of foods that could be selected to help achieve the study goals, but a variety of individual adaptions occurred. After three years, the intervention group lowered mean dietary intake of total and saturated fat from a mean of 34% at baseline to 28.6%, and serum LDL-C was significantly lower than usual care by 0.09mmol/L (3.3mg/dL, p=.02). These data illustrate adaptation of dietary behavior to achieve the goal nutrient levels, but quantifying the specific changes in eating patterns, food choices and preparation techniques requires further programming and data analyses than what has been already accomplished in this study. Proposed are additional food group analyses to quantify and compare specific food choices adopted within and between groups. By utilizing the GO! vs. WHOA! system, the dietary data collected from over 6,000 recalls will be configured to identify lower vs. higher fat food choices across the overall eating pattern. This will permit better understanding about the self-selected dietary changes that were made in DISC among those children who adhered to the diet, document the level of nutrient adequacy achieved among this cohort and provide potential insights for future translational studies on reduced fat eating in this age group.