B-Vitamin Intake and Blood Pressure: The INTERMAP Study

B 族维生素摄入量与血压：INTERMAP 研究

• 批准号: 6601290
• 负责人: LINDA Verner VAN HORN
• 金额: $ 12.43万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6601290
• 关键词: American; Chinese; European; Japanese; blood pressure; body composition; clinical research; diet therapy; dietary supplements; disease /disorder prevention /control; epidemiology; folate; high performance liquid chromatography; human data; nuclear magnetic resonance spectroscopy; nutrient intake activity; nutrient requirement; nutrition related tag; questionnaires; riboflavin; thiamine; vitamin B complex; vitamin B6

DESCRIPTION (provided by applicant): INTERMAP is a basic epidemiologic investigation to clarify unanswered questions on the role of macronutrients and micronutrients in the etiology of unfavorable blood pressure (BP) patterns prevailing for most middle-aged and older individuals. Supported by NHLBI, ten primary hypotheses, four subgroup hypotheses and multiple exploratory questions on diet and BP are being addressed in this high-quality international cooperative 17-sample population study of 4,680 men and women ages 40-59 from four countries (China, Japan, UK, US) - of varied ethnic-racial and sociodemographic backgrounds - consuming diverse diets. Analyses use extensive data on nutrient intake from four 24-hour recalls and the 4 country databases (developed by INTERMAP) on nutrient composition of all reported foods (data on 71 nutrients), and from two 24-hr urine collections on Na, K, Ca, Mg, urea, creatinine, volume and microalbuminuria. NHLBI-funded research in progress or pending includes analysis of urinary amino acids of each individual, coding of reported dietary supplements, and special NMR-HPLC analyses of 24-hour urine specimens. New work proposed here - on B vitamin intake and BP - is novel, exploratory, knowledge-generating and "pre-competitive" in nature, in keeping with the aims of this RFA. It is based on new and unprecedented findings, from ongoing INTERMAP analyses for its 2,195 US participants. These data indicate that lower dietary thiamin, riboflavin, B6, and folate (considered singly) is associated with higher systolic BP (SBP), and plays a role in the higher SBP of African-Americans and of less educated Americans of all ethnicities. These results open up a new research area, on B vitamin intake and BP. These analyses were done only for US participants since data on B vitamin composition of foods are missing for Chinese, Japanese, and UK participants. This application requests funds to overcome this data gap, and make possible comprehensive analyses for all 4,680 participants on relations of B vitamin intake (from foods, supplements, and foods plus supplements) to BP, and to other variables, i.e., to make links between data on B vitamin and other nutrient intakes, urinary data on multiple metabolic characteristics (elucidated by routine and special NMR-HPLC analyses), and SBP/DBP - links not available on populations from any other research.

描述（由申请人提供）： INTERMAP 是一项基本的流行病学调查，旨在澄清大量营养素和微量营养素在大多数中老年人普遍存在的不良血压 (BP) 模式病因学中的作用这一尚未解答的问题。在 NHLBI 的支持下，这项高质量的国际合作性 17 个样本人口研究解决了关于饮食和血压的 10 个主要假设、4 个亚组假设和多个探索性问题，研究对象为来自 4 个国家（中国、日本、英国、美国）的 4,680 名 40-59 岁男性和女性，他们具有不同的民族、种族和社会人口背景，饮食多样化。分析使用了来自四次 24 小时召回的大量营养摄入数据和所有报告食品营养成分的 4 个国家数据库（由 INTERMAP 开发）（有关 71 种营养素的数据），以及两次 24 小时尿液收集中的钠、钾、钙、镁、尿素、肌酸酐、体积和微量白蛋白尿。 NHLBI 资助的正在进行或待决的研究包括对每个人的尿液氨基酸进行分析、对报告的膳食补充剂进行编码以及对 24 小时尿液样本进行特殊 NMR-HPLC 分析。这里提出的关于 B 族维生素摄入和血压的新工作本质上是新颖的、探索性的、知识生成的和“竞争前”的，符合本次 RFA 的目标。它基于对 2,195 名美国参与者正在进行的 INTERMAP 分析的新的、前所未有的发现。这些数据表明，较低的膳食硫胺素、核黄素、B6 和叶酸（单独考虑）与较高的收缩压 (SBP) 相关，并且在非裔美国人和所有种族受教育程度较低的美国人的较高 SBP 中发挥着作用。这些结果开辟了一个关于 B 族维生素摄入和血压的新研究领域。这些分析仅针对美国参与者进行，因为缺少中国、日本和英国参与者食物 B 族维生素成分的数据。该申请要求提供资金来克服这一数据差距，并对所有 4,680 名参与者进行全面分析，了解 B 族维生素摄入量（来自食物、补充剂和食物加补充剂）与血压和其他变量的关系，即在 B 族维生素和其他营养素摄入量数据、多种代谢特征的尿液数据之间建立联系（通过常规和特殊 NMR-HPLC 阐明） 分析）和 SBP/DBP - 任何其他研究中的人群均无法获得链接。