B-Vitamin Intake and Blood Pressure: The INTERMAP Study

描述(由申请人提供)： InterMAP是一项基本的流行病学调查，旨在澄清有关大量营养素和微量营养素在大多数中老年人普遍存在的不良血压(BP)模式的病因中所扮演的角色的未回答的问题。在NHLBI的支持下，关于饮食和血压的10个基本假设、4个亚组假设和多个探索性问题将在这项高质量的国际合作人口研究中得到解决，该研究包括来自四个国家(中国、日本、英国、美国)的4,680名年龄在40-59岁之间的男性和女性-不同的种族和社会人口背景-消费多样化的饮食。分析使用了四次24小时召回的营养素摄入量和4个国家数据库(由INTERMAP开发)关于所有报告食物的营养成分的广泛数据(关于71种营养素的数据)，以及关于钠、钾、钙、镁、尿素、肌酐、体积和微量白蛋白尿的两次24小时尿液收集。NHLBI资助的正在进行或即将进行的研究包括对每个人的尿氨基酸进行分析，对已报告的膳食补充剂进行编码，以及对24小时尿样进行特殊的核磁共振-高效液相分析。这里提出的新工作--关于B族维生素摄入量和血压--是新颖的、探索性的、产生知识的和“竞争前”性质的，与本RFA的目标一致。它是基于对INTERMAP对2195名美国参与者进行的正在进行的分析得出的前所未有的新发现。这些数据表明，较低的饮食硫胺素、核黄素、B6和叶酸(单独考虑)与较高的收缩压(SBP)有关，并在非裔美国人和所有种族受教育程度较低的美国人的较高SBP中发挥作用。这些结果开辟了一个新的研究领域，即维生素B摄入量与血压的关系。这些分析只针对美国参与者，因为中国、日本和英国参与者缺乏食物中B族维生素成分的数据。这项申请需要资金来克服这一数据差距，并使所有4,680名参与者有可能对B维生素摄入量(从食物、补充剂和食物加补充剂)与血压和其他变量的关系进行综合分析，即在B维生素和其他营养物质摄入量的数据、关于多种代谢特征的尿液数据(通过常规和特殊的核磁共振-高效液相色谱分析阐明)以及任何其他研究的人群中没有的SBP/DBP链接之间建立联系。

DESCRIPTION (provided by applicant): INTERMAP is a basic epidemiologic investigation to clarify unanswered questions on the role of macronutrients and micronutrients in the etiology of unfavorable blood pressure (BP) patterns prevailing for most middle-aged and older individuals. Supported by NHLBI, ten primary hypotheses, four subgroup hypotheses and multiple exploratory questions on diet and BP are being addressed in this high-quality international cooperative 17-sample population study of 4,680 men and women ages 40-59 from four countries (China, Japan, UK, US) - of varied ethnic-racial and sociodemographic backgrounds - consuming diverse diets. Analyses use extensive data on nutrient intake from four 24-hour recalls and the 4 country databases (developed by INTERMAP) on nutrient composition of all reported foods (data on 71 nutrients), and from two 24-hr urine collections on Na, K, Ca, Mg, urea, creatinine, volume and microalbuminuria. NHLBI-funded research in progress or pending includes analysis of urinary amino acids of each individual, coding of reported dietary supplements, and special NMR-HPLC analyses of 24-hour urine specimens. New work proposed here - on B vitamin intake and BP - is novel, exploratory, knowledge-generating and "pre-competitive" in nature, in keeping with the aims of this RFA. It is based on new and unprecedented findings, from ongoing INTERMAP analyses for its 2,195 US participants. These data indicate that lower dietary thiamin, riboflavin, B6, and folate (considered singly) is associated with higher systolic BP (SBP), and plays a role in the higher SBP of African-Americans and of less educated Americans of all ethnicities. These results open up a new research area, on B vitamin intake and BP. These analyses were done only for US participants since data on B vitamin composition of foods are missing for Chinese, Japanese, and UK participants. This application requests funds to overcome this data gap, and make possible comprehensive analyses for all 4,680 participants on relations of B vitamin intake (from foods, supplements, and foods plus supplements) to BP, and to other variables, i.e., to make links between data on B vitamin and other nutrient intakes, urinary data on multiple metabolic characteristics (elucidated by routine and special NMR-HPLC analyses), and SBP/DBP - links not available on populations from any other research.