B-Vitamin Intake and Blood Pressure: The INTERMAP Study

描述（由申请人提供）： INTERMAP是一项基本的流行病学调查，旨在澄清关于常量营养素和微量营养素在大多数中年和老年人普遍存在的不良血压（BP）模式病因学中的作用的未回答问题。在NHLBI的支持下，在这项高质量的国际合作17样本人群研究中，对来自四个国家（中国，日本，英国，美国）的4，680名年龄在40-59岁之间的男性和女性进行了10个主要假设，4个亚组假设和多个关于饮食和BP的探索性问题-不同的种族和社会人口背景-消费不同的饮食。分析使用了来自4次24小时召回和4个国家数据库（由INTERMAP开发）的关于所有报告食物营养成分（71种营养素数据）的营养素摄入量的广泛数据，以及来自两次24小时尿液采集的Na，K，Ca，Mg，尿素，肌酐，尿量和微量白蛋白尿的数据。 NHLBI资助的研究正在进行或正在进行中，包括分析每个人的尿氨基酸，报告的膳食补充剂的编码，以及对24小时尿液标本的特殊NMR-HPLC分析。这里提出的关于B族维生素摄入量和血压的新工作是新颖的、探索性的、知识产生的和“竞争前”的，与本RFA的目标一致。它是基于新的和前所未有的发现，从正在进行的INTERMAP分析其2,195美国参与者。这些数据表明，较低的饮食硫胺素，核黄素，B6和叶酸（单独考虑）与较高的收缩压（SBP）相关，并在非洲裔美国人和所有种族的受教育程度较低的美国人的较高SBP中发挥作用。这些结果为B族维生素摄入量与血压的关系开辟了一个新的研究领域。这些分析仅针对美国参与者进行，因为缺少中国、日本和英国参与者的食物B族维生素组成数据。该申请要求提供资金以克服这一数据缺口，并对所有4，680名参与者进行全面分析，以了解B族维生素摄入量（从食物、补充剂和食物加补充剂）与BP和其他变量的关系，即，建立B族维生素和其他营养素摄入量数据、多种代谢特征的尿液数据（通过常规和特殊NMR-HPLC分析阐明）和SBP/DBP之间的联系-任何其他研究的人群均未提供联系。

DESCRIPTION (provided by applicant): INTERMAP is a basic epidemiologic investigation to clarify unanswered questions on the role of macronutrients and micronutrients in the etiology of unfavorable blood pressure (BP) patterns prevailing for most middle-aged and older individuals. Supported by NHLBI, ten primary hypotheses, four subgroup hypotheses and multiple exploratory questions on diet and BP are being addressed in this high-quality international cooperative 17-sample population study of 4,680 men and women ages 40-59 from four countries (China, Japan, UK, US) - of varied ethnic-racial and sociodemographic backgrounds - consuming diverse diets. Analyses use extensive data on nutrient intake from four 24-hour recalls and the 4 country databases (developed by INTERMAP) on nutrient composition of all reported foods (data on 71 nutrients), and from two 24-hr urine collections on Na, K, Ca, Mg, urea, creatinine, volume and microalbuminuria. NHLBI-funded research in progress or pending includes analysis of urinary amino acids of each individual, coding of reported dietary supplements, and special NMR-HPLC analyses of 24-hour urine specimens. New work proposed here - on B vitamin intake and BP - is novel, exploratory, knowledge-generating and "pre-competitive" in nature, in keeping with the aims of this RFA. It is based on new and unprecedented findings, from ongoing INTERMAP analyses for its 2,195 US participants. These data indicate that lower dietary thiamin, riboflavin, B6, and folate (considered singly) is associated with higher systolic BP (SBP), and plays a role in the higher SBP of African-Americans and of less educated Americans of all ethnicities. These results open up a new research area, on B vitamin intake and BP. These analyses were done only for US participants since data on B vitamin composition of foods are missing for Chinese, Japanese, and UK participants. This application requests funds to overcome this data gap, and make possible comprehensive analyses for all 4,680 participants on relations of B vitamin intake (from foods, supplements, and foods plus supplements) to BP, and to other variables, i.e., to make links between data on B vitamin and other nutrient intakes, urinary data on multiple metabolic characteristics (elucidated by routine and special NMR-HPLC analyses), and SBP/DBP - links not available on populations from any other research.