BARBADOS EYE STUDY READING CENTER

巴巴多斯眼科阅读中心

• 批准号: 3559592
• 负责人: ANDREW P SCHACHAT
• 金额: $ 10.08万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 1991-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3559592
• 关键词: South America; blood pressure; body weight; cataract; epidemiology; eye disorder diagnosis; eye refraction disorder; family; fundus oculi; glaucoma; glaucoma test; health surveys; human age group; human subject; intraocular fluid; intraocular pressure; photography; public health; retina degeneration; visual fields

Open angle glaucoma is a major cause of visual impairment in Black populations. Clinical experience suggests an unusually high glaucoma risk in Barbados, W.I., where most citizens are of African descent. The disease is the major cause of blindness, presenting early and with advanced visual loss. An epidemiologic study is proposed with the major goals of a) measuring the prevalence of glaucoma and its associated impairment, b) evaluating its risk factors, and c) obtaining data to develop interventions to prevent or control visual loss. The proposed research would be the first comprehensive glaucoma study to cover an entire country. Because the disease is a major problem in Black populations, the aims of the proposed study are of widespread public health significance. The secondary goals of the study are to measure prevalence and evaluate risk factors for age-related cataract, macular degeneration, and diabetic retinopathy. Population based epidemiologic data on these diseases are limited or non-existent for Black populations; the proposed study would provide such information at limited additional cost. The above goals would be attained by examining a random sample of 4000 persons 40-84 years in a Ministry of Health polyclinic. Participants could have measurements of intraocular pressure, visual fields, visual acuity, refraction, height, weight, and blood pressure, as fundus photographs and an interview on medical, family, and other risk factor history. Blood testing would be performed on cases and a sample of non-cases. The Fundus Photograph Reading Center of the BES will evaluate the fundus photographs of all participants in the study. The optic discs will be evaluated for glaucomatous changes. Diabetic and age-related changes of the macula will also, be recorded. The fundus photographs will provide an evaluation of fundus pathology on all participants. The final diagnosis will be determined by the Coordinating Center based on positive findings of the clinical examination and the fundus photographs.

开角型青光眼是黑人视力损害的主要原因 人口。 临床经验表明， 青光眼风险在巴巴多斯，西弗吉尼亚州，那里的大多数公民都是非洲人 血统. 这种疾病是失明的主要原因， 早期和晚期视力丧失。 一项流行病学研究表明， 提出的主要目标是：a）衡量 青光眼及其相关损害，B）评估其风险 c）获取数据以制定干预措施， 或控制视力丧失。 这项拟议的研究将是第一个 全面的青光眼研究覆盖整个国家。 因为 这种疾病是黑人人口的一个主要问题， 拟议的研究具有广泛的公共卫生意义。 这项研究的次要目标是测量患病率， 评估年龄相关性白内障、黄斑 变性和糖尿病视网膜病变。 基于人群 关于这些疾病的流行病学数据有限或不存在 对于黑人人口;拟议的研究将提供这样的 以有限的额外费用提供信息。 上述目标将通过随机抽样检查 4000名40-84岁的人在卫生部的一家综合诊所接受治疗。 参与者可以测量眼内压， 视野、视力、屈光、身高、体重和血液 压力，眼底照片和医疗采访， 家族史和其他危险因素史。 血液检测将是 在病例和非病例样本上进行。 北京谱仪眼底照片阅读中心将对 所有参与者的眼底照片。 视 将评估椎间盘是否有昏迷性变化。 糖尿病和 还将记录黄斑的年龄相关变化。 眼底照片将提供眼底评估 所有参与者的病理学。 最后的诊断将是 由协调中心根据积极的调查结果确定 临床检查和眼底照片