BARBADOS INCIDENCE STUDY OF EYE DISEASES READING CENTER

巴巴多斯眼病发病率研究阅读中心

• 批准号: 3559599
• 负责人: ANDREW P SCHACHAT
• 金额: $ 15.99万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 1997-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3559599
• 关键词: Caribbean islands; cataract; diabetic retinopathy; diagnosis quality /standard; epidemiology; eye disorder; eye fundus photography; glaucoma; health surveys; human subject; macular degeneration

The objectives of the Barbados Incidence Study of Eye Diseases (BISED) are: (1) to determine the incidence and progression of open-angle glaucoma, age- related cataract, diabetic retinopathy and age-related macular degeneration, (2) to evaluate risk factors for the incidence of the above eye diseases, using baseline data collected during the previous Barbados Eye Study (BES) examination, and (3) to determine the incidence and progression of visual acuity impairment and their associated factors This proposal outlines the rationale for and function of the BISED Fundus Photography Reading Center (FPRC). The FPRC will provide data to classify fundus photographs in a standardized manner. The FPRC will evaluate the fundus photographs of all participants in the incidence study according to the same grading scheme used in the prevalence study, which evaluates the optic disc for glaucomatous changes and the macula for diabetic and age- related changes. The gradings from the two studies will be compared to identify participants with newly identified pathology or changes in previous pathology. In addition to repeating the prevalence grading protocol, an additional side-by-side comparison grading will be performed to identify progression of disease pathology not presently included in the prevalence study grading scheme. The FPRC personnel who attained excellent reproducibility (measured by Kappa statistics) with the original BES grading scheme, remain on staff. Findings from clinical examinations are notoriously variable. Incorporation of data from the FPRC improves the quality of the study by supplying reproducible independent gradings on all photographed participants. Since the BES protocol does not refer everyone for ophthalmic examination, the photographic findings will be the only ophthalmic finding on approximately 1/4 of the participants.

巴巴多斯眼病发病率研究的目标是： (1)为确定开角型青光眼的发病和进展，年龄- 相关性白内障、糖尿病视网膜病变和老年性黄斑 退行性疾病，(2)评估上述疾病发生的危险因素 眼科疾病，使用在前巴巴多斯期间收集的基线数据 眼科检查(BES)，以及(3)确定发病率和 视力损害的进展及其相关因素 本提案概述了BISED基础的基本原理和功能 摄影阅读中心(FPRC)。Fprc将提供数据进行分类 以标准化方式拍摄眼底照片。家庭关系委员会将评估 根据发病率研究的所有参与者的眼底照片 与流行率研究中使用的相同评分方案相同，该方案评估 视盘用于青光眼改变，黄斑用于糖尿病和年龄- 相关变化。这两项研究的评分将与 确定具有新确定的病理或以下方面变化的参与者 以前的病理学。除了重复患病率分级之外 协议，将执行额外的并排比较评分 以确定目前未包括在 流行率研究评分方案。取得优异成绩的FPRC人员 原始BES的重复性(用Kappa统计量衡量) 评级方案，继续留任员工。 临床检查的结果是出了名的多变。 纳入研究中心的数据通过以下方式提高了研究质量 为所有拍摄的照片提供可复制的独立放坡 参与者。由于BES协议并不将每个人都提到 眼科检查，唯一的照相结果将是 大约1/4的参与者有眼科发现。