COMPUTER SYSTEM FOR PATIENT DATA-BASE MANAGEMENT

用于患者数据库管理的计算机系统

• 批准号: 3520634
• 负责人: ANDREW P SCHACHAT
• 金额: $ 24.4万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-06-07 至 1997-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3520634
• 关键词: biomedical equipment purchase; clinical trials; computer center; information systems; longitudinal human study; patient /disease registry; statistics /biometry; therapy; vision disorders

This application is for a computer to expand our clinical research of a variety of diseases and problems that contribute to significant visual loss for Americans. The Wilmer Institute opened its Computer Center in 1976 to service all of its many-faceted research projects. An IBM 11/45 running under the UNIX operating systems sufficed for about 10 yrs. It was finally replaced by a VAX 11/750; the current system. Meanwhile, demand for computer useage has grown exponentially. Most of the growth is related to management of large patient data-bases in longitudinal studies with eye diseases and their treatment. An example of this is the Clinical Trial in which one tests the hypothesis that a certain treatment of disease is beneficial in the long run. This can require about 2,000 patients be studied requiring collaboration between medical schools throughout the country with one acting as Coordinating Center. Some patients will be treated one way, some another. Are patients are followed for years and the date can easily consist of 2,000 pieces of information per patient. Statistical analysis is important in the initial design of the Trial and data analysis is constantly needed to monitor progress, but the main use of the computer is in administration and management of the Trial: recalling patients, checking protocol completeness, and a thousand other details. Our first Clinical Trial, and our most famous to date, concerned the use of lasers to coagulate abnormal growth of blood vessels in age-related macular degeneration-a major cause of vision loss in older Americans. This massive Clinical Trial, begun in 1979, had shown by 1982, that laser treatment was an obvious success. Since then, with the enthusiastic support of the National Eye Institute, other Clinical Trials, as well as Natural History and Genetic Studies, have evolved in Wilmer bearing on such eye problems as ocular melanoma, corneal transplantation, glaucoma, optic neuritis, juvenile diabetes, intraocular lens implantation, retinitis pigmentosa, the Marfan syndrome and congenital esotropia. This rapid growth has simply swamped the Computer Center. Current work is now seriously impeded, and contemplated expansion of these projects and the additions of new ones will be impossible without expanded computer power. We feel that supplementing our system with a Pyramid 9815 Supermini-Computer will break this bottleneck and permit our planned expanded research for at least the next ten years.

此应用程序是为计算机扩展我们的临床研究的一个 各种疾病和问题，有助于显着的视觉 美国人的损失。 威尔默研究所于1976年开设了计算机中心，为所有 其多方面的研究项目。 在UNIX下运行的IBM 11/45 操作系统足够了大约10年。它最终被一个 VAX 11/750;当前系统。 与此同时，对计算机使用的需求呈指数级增长。 大部分 这种增长与大型患者数据库的管理有关， 眼科疾病及其治疗的纵向研究。 的示例 这是一个临床试验，其中一个测试的假设， 从长远来看，某种疾病的治疗是有益的。 这可以 需要对大约2,000名患者进行研究， 全国各地的医学院，其中一所作为协调 中心 有些患者会接受一种治疗方式，有些则会接受另一种治疗方式。 是 患者被跟踪数年，日期可以很容易地包括2000 每个病人的信息量。 统计分析在 不断需要试验的初始设计和数据分析， 监控进度，但计算机的主要用途是管理 和试验管理：召回患者，检查方案 完整性和其他一千个细节。 我们的第一个临床试验，也是迄今为止最著名的一个， 激光凝固血管的异常生长在年龄相关的 黄斑变性-美国老年人视力丧失的主要原因。 这项始于1979年的大规模临床试验表明，到1982年，激光 治疗取得了明显的成功。 从那时起，随着热情 国家眼科研究所，其他临床试验，以及 自然史和遗传学研究，已经在威尔默的轴承演变， 诸如眼部黑色素瘤、角膜移植、青光眼 视神经炎，青少年糖尿病，眼内透镜植入， 视网膜色素变性、马凡氏综合征和先天性内斜视。 这种快速增长简直淹没了计算机中心。 这的工作要 现在严重受阻，并考虑扩大这些项目， 如果不扩充计算机， 动力. 我们觉得用金字塔9815来补充我们的系统 超级微型计算机将打破这一瓶颈，使我们的计划 至少在未来十年内扩大研究。