BARBADOS INCIDENCE STUDY OF EYE DISEASES READING CENTER

巴巴多斯眼病发病率研究阅读中心

• 批准号: 3559593
• 负责人: ANDREW P SCHACHAT
• 金额: $ 9.96万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 1997-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3559593
• 关键词: Caribbean islands; cataract; diabetic retinopathy; diagnosis quality /standard; epidemiology; eye disorder; eye fundus photography; glaucoma; health surveys; human subject; retina degeneration

The objectives of the Barbados Incidence Study of Eye Diseases (BISED) are: (1) to determine the incidence and progression of open-angle glaucoma, age- related cataract, diabetic retinopathy and age-related macular degeneration, (2) to evaluate risk factors for the incidence of the above eye diseases, using baseline data collected during the previous Barbados Eye Study (BES) examination, and (3) to determine the incidence and progression of visual acuity impairment and their associated factors This proposal outlines the rationale for and function of the BISED Fundus Photography Reading Center (FPRC). The FPRC will provide data to classify fundus photographs in a standardized manner. The FPRC will evaluate the fundus photographs of all participants in the incidence study according to the same grading scheme used in the prevalence study, which evaluates the optic disc for glaucomatous changes and the macula for diabetic and age- related changes. The gradings from the two studies will be compared to identify participants with newly identified pathology or changes in previous pathology. In addition to repeating the prevalence grading protocol, an additional side-by-side comparison grading will be performed to identify progression of disease pathology not presently included in the prevalence study grading scheme. The FPRC personnel who attained excellent reproducibility (measured by Kappa statistics) with the original BES grading scheme, remain on staff. Findings from clinical examinations are notoriously variable. Incorporation of data from the FPRC improves the quality of the study by supplying reproducible independent gradings on all photographed participants. Since the BES protocol does not refer everyone for ophthalmic examination, the photographic findings will be the only ophthalmic finding on approximately 1/4 of the participants.

巴巴多斯眼病发病率研究（BISED）的目标是： (1)为了确定开角型青光眼的发病率和进展，年龄- 相关性白内障、糖尿病视网膜病变和年龄相关性黄斑病变 变性，（2）评估上述发生率的危险因素 眼疾病，使用巴巴多斯上届会议期间收集的基线数据， 眼科研究（BES）检查，以及（3）确定发病率和 视力损害的进展及其相关因素 本提案概述了工商支助和发展基金的基本原理和职能 摄影阅读中心。 FPRC将提供数据， 标准化的眼底照片。 FPRC将评估 发病率研究中所有参与者的眼底照片， 流行率研究中使用的相同分级方案， 视神经盘用于青光眼性改变，黄斑用于糖尿病和老年性改变， 相关变化。 两项研究的评分将与 识别新发现的病理或变化的参与者， 以前的病理学。 除了重复患病率分级 方案，将进行额外的并行比较分级 以确定目前未包括在 流行率研究分级方案。 中非复兴人民阵线的工作人员， 与原始BES的再现性（通过Kappa统计测量） 等级制度，继续留任。 众所周知，临床检查的结果是多变的。 纳入FPRC的数据通过以下方式提高了研究质量： 为所有拍摄的照片提供可重复的独立分级 参与者 由于BES协议并不要求每个人都 眼科检查，摄影结果将是唯一的 大约1/4的参与者的眼科发现。