ELECTROPHYSIOLOGICAL STUDIES OF ACUTE AND CHRONIC ALCOHOL CONSUMPTION

尽管酒精明显会导致精神过程的改变和 行为，也许是因为这些影响是如此伟大和无处不在 事实证明，它们很难被定性。全球表现 通常用于记录这种影响的措施，同时演示 显然，他们的存在往往提供的信息很少，关于具体 作用地点或作用机制。本研究的目的是解析 酒精对周围神经、感觉、认知和神经的单独影响 使用事件相关脑电势的运动系统。这些 潜力是在性能提供的广泛背景下研究的， 心理生理学、神经心理学、神经放射学和 神经精神病学数据。 研究了酒精对三类受试者的影响：1) 急性给药的效果在正常志愿者中进行了检查， 关于剂量-反应关系，效应的时间过程，以及 与血液酒精水平的关系；2)脑电活动 结合神经心理学数据，对社交饮酒者进行了研究 试图分析适度饮酒的影响； 3)戒酒，包括与酒精中毒有关的精神病患者 对减值进行研究，以表征赤字，检查短期- 以及禁欲期间的长期康复效果(如果有的话)，并检查 各种治疗策略的疗效。

Although alcohol clearly leads to alterations in mental processes and behavior, it is perhaps because these efects are so great and so pervasive that they have proven difficult to characterize. The global performance measures commonly used to document such effects, while demonstrating clearly their presence, often provide little information as to the specific locus or mechanism of effect. The present research aims to parse the separate effects of alcohol on peripheral nerve, sensory, cognitive and motor systems using event related brain electrical potentials. These potentials are studied within a broad context provided by performance, psychophysiological, neuropsychological, neuroradiological and neuropsychiatric data. The effects of alcohol are investigated in three classes of subjects: 1) The effects of acute administration are examined in normal volunteers with respect to dose-response relationships, the temporal course of effect, and relationship to blood alcohol levels; 2) Brain electrical activity is studied, in conjunction with neuropsychological data, in social drinkers in an attempt to assay the effects of moderate levels of alcohol consumption; 3) Abstaining alcoholics, including those with alcoholism-related mental impairment, are studied to characterize the deficits, to examine the short- and long-term recovery effects, if any, during abstinence, and to examine the efficacy of various treatment strategies.