ELECTROPHYSIOLOGICAL STUDIES OF ACUTE AND CHRONIC ALCOHOL CONSUMPTION

急性和慢性饮酒的电生理学研究

• 批准号: 4687737
• 负责人: J ROHRBAUGH
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4687737
• 关键词: alcoholic beverage consumption; alcoholism /alcohol abuse; alcoholism /alcohol abuse therapy; blood chemistry; brain electrical activity; cognition; electrophysiology; evoked potentials; human subject; interview; neuromuscular system; neuropsychology; performance; peripheral nervous system; psychophysiology; sensorimotor system; toxicology

Although alcohol clearly leads to alterations in mental processes and behavior, it is perhaps because these effects are so great and so pervasive that they have proven difficult to characterize. The global performance measures commonly used to document such effects clearly demonstrate their presence but often provide little information as to the specific locus or mechanism of effect. The present research aims to parse the separate effects of alcohol on peripheral nerve, sensory, cognitive, and motor systems, using event-related brain electrical potentials. These potentials are studied within a broad context provided by performance, psychophysiological, neuropsychological, neuroradiological, and neuropsychiatric data. The effects of alcohol are investigated in three classes of subjects: (1) normal volunteers, in whom the effects of acute administration are examined with respect to dose-response relationships, the temporal course of effect, and relationship to blood alcohol levels; (2) social drinkers, in whom brain electrical activity is studied, in conjunction with neuropsychological data, in an attempt to assay the effects of moderate levels of alcohol consumption; and (3) abstaining alcoholics (including those with alcoholism-related mental impairment) in whom deficits are characterized, short- and long-term recovery effects (if any) during abstinence are examined, and the efficacy of various treatment strategies is examined.

虽然酒精明显会导致心理过程的改变， 也许是因为这些影响是如此之大，如此之普遍， 他们已经证明很难描述。 全球绩效 通常用来记录这种影响的措施清楚地表明， 存在，但往往提供很少的信息，以具体的基因座或 作用机制。 本研究旨在解析分离的 酒精对周围神经、感觉、认知和运动的影响 系统，使用事件相关的脑电位。 这些潜力 是在性能提供的广泛背景下研究的， 心理生理学、神经心理学、神经放射学和 神经精神病学数据。 酒精的影响在三类受试者中进行了研究：（1） 正常志愿者，在其中检查急性给药的效果 关于剂量-反应关系，作用的时间过程， 与血液酒精水平的关系;（2）社交饮酒者，其中 研究脑电活动， 神经心理学数据，试图分析适度的 饮酒水平;及（3）戒酒（包括 与酒精中毒有关的精神障碍）， 特征、短期和长期恢复效果（如有） 禁欲检查，以及各种治疗策略的疗效 进行了检查。