ELECTROPHYSIOLOGICAL STUDIES OF ACUTE AND CHRONIC ALCOHOL CONSUMPTION

尽管酒精明显会导致精神过程的改变和 行为，可能是因为这些影响是如此巨大和无处不在 事实证明，它们很难被定性。全球表现 通常用于记录这种影响的措施清楚地表明了它们的 存在，但通常提供的信息很少，关于特定的位置或 作用机制。本研究的目的是分析不同的 酒精对周围神经、感觉、认知和运动的影响 系统，使用与事件相关的脑电势。这些势能 在由Performance提供的广泛背景下进行研究， 心理生理学、神经心理学、神经放射学和 神经精神病学数据。 研究了酒精对三类受试者的影响：(1) 正常志愿者，检查急性给药的效果 关于剂量-反应关系，作用的时间过程， 以及与血液酒精水平的关系；(2)社交饮酒者，其中 脑电活动的研究，与 神经心理学数据，试图分析适度的 饮酒水平；及(3)戒酒(包括 与酒精中毒相关的精神障碍者) 具有特征的短期和长期恢复效果(如果有) 检查戒酒情况，以及各种治疗策略的效果 被检查过了。

Although alcohol clearly leads to alterations in mental processes and behavior, it is perhaps because these effects are so great and so pervasive that they have proven difficult to characterize. The global performance measures commonly used to document such effects clearly demonstrate their presence but often provide little information as to the specific locus or mechanism of effect. The present research aims to parse the separate effects of alcohol on peripheral nerve, sensory, cognitive, and motor systems, using event-related brain electrical potentials. These potentials are studied within a broad context provided by performance, psychophysiological, neuropsychological, neuroradiological, and neuropsychiatric data. The effects of alcohol are investigated in three classes of subjects: (1) normal volunteers, in whom the effects of acute administration are examined with respect to dose-response relationships, the temporal course of effect, and relationship to blood alcohol levels; (2) social drinkers, in whom brain electrical activity is studied, in conjunction with neuropsychological data, in an attempt to assay the effects of moderate levels of alcohol consumption; and (3) abstaining alcoholics (including those with alcoholism-related mental impairment) in whom deficits are characterized, short- and long-term recovery effects (if any) during abstinence are examined, and the efficacy of various treatment strategies is examined.