NUTRITIONAL EFFECTS ON ESSENTIAL FATTY ACID COMPOSITION

我们的假设是酗酒会导致 多不饱和脂质从许多组织，并导致改变代谢 类花生酸 肝脏和其他器官的这种变化， 组织可能会导致与以下疾病相关的病理变化： 酒精中毒 花生四烯酸（20：4 n6）和其他n-6脂肪酸的损失 在我们对暴露于酒精的大鼠组织的研究中观察到， 在酗酒者的血细胞中。 这就引出了一个问题， 有可能通过饮食来替代这些必需脂肪酸， 操纵 动物研究表明，提供n-6 前体，18：3 n6在饮食中可以部分预防酒精诱导的 与高18：1 n9或长链饲料相比，肝脏20：4 n6损失 n-3脂肪酸。 一项针对戒酒者的临床研究表明， 表明多不饱和化合物的组成在复合物中发生了变化 血细胞中的时尚 血小板减少了20：4 n6种 酗酒者中几种非必需磷脂物质的增加 在准入。 大多数这些变化在4周后恢复正常 戒断 在红细胞中，18：2n 6丢失， 在非必需物种18：0和18：1 n9中。 没有一个物种 在戒酒开始时异常， 红细胞4周。 花生四烯酸种类在PE中增加， PS的下降。 磷脂含量普遍增加 酗酒者红细胞膜分子种类不对称性。

It is our hypothesis that alcohol abuse leads to the depletion of polyunsaturated lipids from many tissues and leads to altered metabolism of eicosanoids. Such changes in the liver as well as in other organs and tissues may contribute to the pathological changes associated with alcoholism. Losses in arachidonic acid (20:4n6) and other n-6 fatty acids have been observed in our studies of alcohol exposed rat tissues as well as in the blood cells of alcoholics. This led to the question as to whether it was possible to replace these essential fatty acids by dietary manipulation. Animal studies have indicated that supplying the n-6 precursor, 18:3n6 in the diet can partially prevent the alcohol-induced loss of liver 20:4n6 when compared to diets high in 18:1n9 or long chain n-3 fatty acids. A clinical study of alcoholics during withdrawal has indicated that the composition of polyunsaturates is altered in a complex fashion in blood cells. Platelets exhibited a loss of a 20:4n6 species with increases in several non-essential phospholipid species in alcoholics at admittance. Most of these changes normalized after 4 weeks of withdrawal. In the erythrocyte, there was a loss of 18:2n6 and an increase in the non-essential species 18:0 and 18:1n9. None of the species that were abnormal at the beginning of alcohol withdrawal had normalized in the erythrocyte by 4 weeks. Arachidonyl species increased in PE while decreasing in PS. There was a generalized increase in phospholipid molecular species asymmetry in the erythrocyte membrane in alcoholics.