A congenic approach to analysing the genomic control of innate immunity in health and disease

淋巴细胞是一种特殊的白色细胞，它可以学习击败身体以前接触过的感染，除了淋巴细胞外，身体还有许多其他防御措施。这些非学习系统经过进化的磨练，通常形成有效的第一道防线。该提案涉及三种：补体和两种高度专业化的白色血细胞，自然杀伤细胞和NKT细胞。该项目将研究特别培育的携带不同版本基因的小鼠，这些基因控制这些防御。将特别注意他们参与自身免疫性疾病，1型糖尿病和狼疮。

In addition to the lymphocytes, which are specialised white cells that can learn to defeat the infections that the body has been previously exposed, the body has a number of other defences. These non-learning systems have been honed by evolution and usually form an effective first-line of defence. This proposal deals with three: complement, and two highly specialised types of white blood cell, the Natural Killer cells and the NKT cells. The project will study mice especially bred to carry different versions of the genes which control these defences. Particular attention will be paid to their involvement in the autoimmune diseases, type 1 diabetes and lupus.