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Minimally Invasive Molecularly Imprinted Conductive Nanoneedle Sensors

微创分子印迹导电纳米针传感器

基本信息

批准号：
EP/V010859/1
负责人：
Hannah Leese
金额：
$ 38.35万
依托单位：
University of Bath
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2021
资助国家：
英国
起止时间：
2021 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FV010859%2F1
关键词：
Minimally Invasive Molecularly Imprinted Conductive

项目摘要

There has been a significant drive in recent years for the development of rapid diagnostics, specifically for sepsis, as there is a crucial time window in which patients need to be diagnosed and treated. Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. The patient's immune system goes into overdrive setting off a series of reactions including widespread inflammation. Sepsis is the leading cause of death from infection, especially if not diagnosed and treated promptly. Rapid, accurate and simple tests are still lacking for sepsis. Diagnosis is an essential part of all healthcare, and sepsis is no exception, and although clinical laboratories offer sensitive, specific assays, such as blood culture and high-throughput immunoassays, they are often time and labour intensive, costly, and dependent on well-trained operators. Point-of-care diagnostics on the other hand, can offer rapid results at site, enabling informed treatments; however, these technologies are still in development. Consequently, for example, antibiotics for suspected bacterial infections can be prescribed without positive diagnosis (increasing the potential risk of antimicrobial resistance), or not prescribed at all when they are really needed (i.e. when sepsis goes undiagnosed). The MIMIC-nano sensors will move beyond the current state-of-the-art by developing minimally invasive sensors with dense arrays of nanoneedles that can sequester and detect targeted biomarkers from interstitial fluid through the development of 'synthetic antibodies' by synthesising molecularly imprinted conductive polymers. The MIMIC-nano sensors will accurately and quickly detect biomarkers specific to inflammation from sepsis, ultimately resulting in optimised diagnosis and treatments. Bringing this need to point-of-care could transform the way patients are diagnosed and treated for antimicrobial infections in the future.

近年来，快速诊断的发展，特别是败血症的快速诊断，有一个重要的驱动力，因为有一个关键的时间窗口，患者需要得到诊断和治疗。脓毒症被定义为由宿主对感染的反应失调引起的危及生命的器官功能障碍。患者的免疫系统进入瘫痪状态，引发一系列反应，包括广泛的炎症。脓毒症是感染导致死亡的主要原因，特别是如果没有及时诊断和治疗。败血症仍然缺乏快速，准确和简单的测试。诊断是所有医疗保健的重要组成部分，脓毒症也不例外，尽管临床实验室提供敏感的特异性检测，如血液培养和高通量免疫测定，但它们通常是时间和劳动密集型的，昂贵的，并且依赖于训练有素的操作人员。另一方面，护理点诊断可以在现场提供快速结果，从而实现知情治疗;然而，这些技术仍在开发中。因此，例如，用于疑似细菌感染的抗生素可以在没有阳性诊断的情况下开处方（增加抗菌素耐药性的潜在风险），或者在真正需要时根本不开处方（即当败血症未被诊断时）。MIMIC-nano传感器将通过开发具有密集纳米针阵列的微创传感器来超越当前最先进的技术水平，该传感器可以通过合成分子印迹导电聚合物来开发“合成抗体”，从而从间质液中隔离和检测目标生物标志物。MIMIC-nano传感器将准确、快速地检测脓毒症炎症特异性生物标志物，最终优化诊断和治疗。将这一需求带到护理点可能会改变未来患者诊断和治疗抗菌素感染的方式。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Antimicrobial releasing hydrogel forming microneedles.

DOI：
10.1016/j.bioadv.2023.213467
发表时间：
2023-05
期刊：
Biomaterials advances
影响因子：
0
作者：
Joseph G. Turner;M. Laabei;Shuxian Li;P. Estrela;H. Leese
通讯作者：
Joseph G. Turner;M. Laabei;Shuxian Li;P. Estrela;H. Leese

Fabrication of a Lactate-Specific Molecularly Imprinted Polymer toward Disease Detection.

DOI：
10.1021/acsomega.2c08127
发表时间：
2023-03-07
期刊：
ACS OMEGA
影响因子：
4.1
作者：
Mustafa, Yasemin L.;Leese, Hannah S.
通讯作者：
Leese, Hannah S.

Conductive Polymer-Coated 3D Printed Microneedles: Biocompatible Platforms for Minimally Invasive Biosensing Interfaces.

DOI：
10.1002/smll.202206301
发表时间：
2023-01
期刊：
Small
影响因子：
13.3
作者：
Antonios Keirouz;Yasemin L. Mustafa;Joseph G. Turner;E. Lay;Ute Jungwirth;F. Marken;H. Leese
通讯作者：
Antonios Keirouz;Yasemin L. Mustafa;Joseph G. Turner;E. Lay;Ute Jungwirth;F. Marken;H. Leese

3D-Printed Hollow Microneedle-Lateral Flow Devices for Rapid Blood-Free Detection of C-Reactive Protein and Procalcitonin

3D 打印空心微针侧流装置，用于快速无血检测 C 反应蛋白和降钙素原