METABOLIC ADAPTATION TO WEIGHT LOSS AND REGAIN

减肥和恢复的代谢适应

• 批准号: 3069682
• 负责人: Kelly Brownell
• 金额: $ 6.07万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-09-29 至 1991-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3069682
• 关键词: adipose tissue; basal metabolism; blood chemistry; body composition; caloric dietary content; data collection; disease /disorder model; enzyme mechanism; gender difference; hormone regulation /control mechanism; insulin; laboratory rat; lipoprotein lipase; nutrient intake activity; nutrition related tag; obesity; thyroid function; weight control

The proposal describes a series of studies with animals and humans to evaluate the metabolic effects of weight loss and regain. These will be done within the Weight Cycling Project, a collaborative project involving investigators from several institutions and disciplines. The primary aim is to determine whether animals and humans adapt to repeated cycles of loss and regain (the "yo-yo syndrome") with increased energy efficiency. Such an effect would make weight loss increasingly difficult with successive cycles because caloric intake would be converted to body weight more efficiently. The first step will be to further develop and refine an animal model of weight cycling and to evaluate metabolic correlates of a cycling effect. Metabolic measures will include lipoprotein lipase activity, adipose tissue morphology, brown fat activity, fat distribution, body composition, metabolic rate, insulin, and thyroid function. Studies will be done using dietary obesity and genetic obesity in animals, and will examine sex differences, pregnancy, the effect of cycling on normal weight animals, and alterations in the nature, frequency, and severity of the loss and regain cycles. Human studies will evaluate weight loss, energy efficiency, and metabolic variables in obese persons who lose and regain on multiple occasions. Studies with wrestlers and football players will be done to evaluate the effects of repeated bouts of loss and regain in highly trained individuals of normal weight. The human and animal studies will provide hypotheses for each other. The active collaboration within a multidisciplinary group of scientists should produce information on the basic processes of body weight regulation. The ultimate aim is to apply the findings to studies on the management and prevention of obesity.

该提案描述了对动物和人类进行的一系列研究 评估体重减轻和恢复对代谢的影响。这些将是 在重量自行车项目中完成，这是一个合作项目，涉及 来自几个机构和学科的调查人员。主要目标是 就是确定动物和人类是否适应反复的损失循环 随着能源效率的提高，重新患上了“溜溜球综合症”。是这样的 一种效果将使减肥变得越来越困难，因为连续 循环，因为卡路里摄入量会更多地转化为体重 效率很高。第一步是进一步发展和完善一个 体重循环动物模型的建立及其代谢相关性的评价 循环效应。代谢指标将包括脂蛋白脂肪酶 活性，脂肪组织形态，棕色脂肪活性，脂肪分布， 身体成分、代谢率、胰岛素和甲状腺功能。研究 将利用动物的饮食肥胖和遗传性肥胖来完成，并将 检查性别差异、怀孕、骑车对正常体重的影响 动物，以及损失的性质、频率和严重程度的变化 并重新获得周期。人体研究将评估减肥、能量 肥胖者失去和恢复的效率和代谢变量 在多个场合。对摔跤运动员和足球运动员的研究将是 做是为了评估反复发作的损失和重新获得的影响 正常体重的训练有素的个体。人类和动物研究将 为彼此提供假设。企业内部的主动协作 多学科的科学家小组应该提供关于 体重调节的基本程序。最终的目标是应用 这一发现是对肥胖管理和预防的研究。