Multiscale Metrology Suite for Next-Generation Health Nanotechnologies

用于下一代健康纳米技术的多尺度计量套件

• 批准号: EP/V028960/1
• 负责人: Zahra Rattray
• 金额: $ 108.71万
• 依托单位: University of Strathclyde
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FV028960%2F1
• 关键词: Multiscale; Metrology; Suite; Next; Generation

The bespoke Multiscale Metrology Suite, will combine powerful leading-edge detectors for measuring nanomaterial properties and transform the measurement of health nanotechnologies. We will build a modular system combining the latest in flow field fractionation technologies with mass spectrometry, Raman and light scattering detectors for the physical and chemical measurement of nanomaterial properties.The requested equipment will enable world-leading researchers at the University of Strathclyde, other UK academic institutions, and industry to accelerate their research into new technologies for healthcare applications and remain competitive in the global race for delivering new innovations in health. Moreover, this equipment will generate new research avenues and partnership opportunities that will create a step-change in the physical and chemical analytical capability and infrastructure for UK health nanotechnology research. This leading-edge suite will ultimately reduce the time and costs associated with delivering new diagnostics and drug treatments, improving quality of life and delivering much needed lifesaving drugs to patients. Strong partnerships with industry partners and government facilities will ensure that this national facility will remain globally-competitive and deliver innovations.

定制的多尺度计量套件将结合强大的尖端探测器来测量纳米材料的特性，并改变健康纳米技术的测量。我们将建立一个模块化系统，将最新的流场分离技术与质谱仪、拉曼和光散射探测器相结合，用于纳米材料性质的物理和化学测量。所需的设备将使斯特拉斯克莱德大学、其他英国学术机构和行业的世界领先研究人员能够加快他们对医疗保健应用的新技术的研究，并在提供新的医疗创新的全球竞赛中保持竞争力。此外，这种设备将创造新的研究途径和合作机会，将在英国健康纳米技术研究的物理和化学分析能力和基础设施方面产生阶段性变化。这一领先的套件最终将减少与提供新的诊断和药物治疗相关的时间和成本，提高生活质量，并向患者提供急需的救命药物。与行业合作伙伴和政府机构的牢固伙伴关系将确保这个国家设施将保持全球竞争力并提供创新。

项目成果

A roadmap for patient-public involvement and engagement (PPIE): Recounting the untold stories of breast cancer patient experiences

患者与公众参与 (PPIE) 路线图：讲述乳腺癌患者经历中不为人知的故事

• DOI: 10.1101/2023.06.19.23291192
• 发表时间: 2023
• 作者: Cunningham M

The differential metabolic signature of breast cancer cellular response to olaparib treatment

乳腺癌细胞对奥拉帕尼治疗反应的差异代谢特征

• DOI: 10.1101/2022.06.14.495928
• 发表时间: 2022
• 作者: Berardi D

Evaluation of the role of KPNA2 mutations in breast cancer prognosis using bioinformatics datasets.

• DOI: 10.1186/s12885-022-09969-4
• 发表时间: 2022-08-10
• 期刊: BMC cancer
• 影响因子: 3.8

Investigating the Impact of Shear Flow on Nanoparticle-Protein Interactions

研究剪切流对纳米颗粒-蛋白质相互作用的影响

• DOI: 10.5920/bjpharm.1131
• 发表时间: 2022
• 期刊: British Journal of Pharmacy
• 作者: Daramy K

Evaluating the impact of experimental shear flow parameters on nanoparticle protein corona formation

评估实验剪切流参数对纳米颗粒蛋白冠形成的影响

• DOI: 10.26434/chemrxiv-2023-6bb7b
• 发表时间: 2023
• 作者: Daramy K