ENDOCRINE EVALUATION OF PANCREATIC TRANSPLANT

胰腺移植的内分泌评估

• 批准号: 3882750
• 负责人: KWAME OSEI
• 金额: --
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3882750
• 关键词: biomarker; diabetes mellitus; endocrine disorder diagnosis; glucose metabolism; histocompatibility; hormone regulation /control mechanism; human subject; insulin; insulin dependent diabetes mellitus; longitudinal human study; pancreas transplantation; postoperative complications

Type I diabetics undergoing pancreatic transplantation surgery will be studied pre-, immediately postsurgery, and in longterm followup to (1) study the impact of physiologic regulation of glucose insulin kinetics and metabolic control (2) provide data on endocrine markers to identify early rejection of the transplanted pancreas; and (3) study the endocrine responses to various stimulatory tests on denervated, systemically drained, pancreas preparation.

接受胰腺移植手术的I型糖尿病患者将 研究(1)的术前、术后即刻和长期随访 研究生理调节对血糖、胰岛素动力学和血糖的影响 代谢控制(2)提供内分泌标记物的数据以早期识别 移植胰腺的排斥反应；以及(3)内分泌研究 系统地对失神经的各种刺激试验的反应 引流，胰腺准备。