EFFICACY OF SOMATOSTATIN ANALOGUE IN TYPE I DIABETES

生长抑素类似物对 I 型糖尿病的疗效

• 批准号: 3861880
• 负责人: KWAME OSEI
• 金额: --
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3861880
• 关键词: blood lipoprotein metabolism; diabetes mellitus therapy; glucose metabolism; hemoglobin As; histocompatibility; human subject; human therapy evaluation; insulin; insulin dependent diabetes mellitus; pancreas transplantation; somatostatin

The objective of this study is to assess the efficacy of combined insulin therapy and subcutaneous injections of somatostatin analogue or placebo in insulin dependent diabetics by monitoring hemoglobin A1 levels, mean blood glucose values and nocturnal glucose production and utilization. The exogenous insulin requirements and the effects on lipid and lipoprotein metabolism will also be monitored.

本研究的目的是评估联合应用胰岛素的疗效。 生长抑素类似物或安慰剂皮下注射治疗 胰岛素依赖型糖尿病患者监测平均血中血红蛋白A1水平 血糖值与夜间葡萄糖的产生和利用。这个 外源性胰岛素需要量及其对血脂和脂蛋白的影响 新陈代谢也将受到监测。