METABOLIC AND ENERGY ASSESSMENT IN NONDIABETIC RELATIVES OF NIDDM PATIENTS

NIDDM 患者非糖尿病亲属的代谢和能量评估

• 批准号: 3761408
• 负责人: KWAME OSEI
• 金额: --
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3761408
• 关键词: African American; adipose tissue; bioenergetics; diabetes mellitus genetics; family genetics; glucose metabolism; human subject; insulin; noninsulin dependent diabetes mellitus; oxidation; pancreatic islet function; thermogenesis

In a population of non-diabetic first degree relatives of black patients with non-insulin dependent diabetes mellitus (NIDDM), this study has the following objectives: (1) to determine the extent of early glucoregulatory abnormalities; (2) evaluate phases of insulin secretion; (3) determine resting metabolic rate, post-glucose thermogenesis, substrate oxidation and relationship to body fat distribution.

在黑人患者的非糖尿病一级亲属中 对于非胰岛素依赖型糖尿病 (NIDDM)，本研究 目标如下： (1) 确定早期的程度 血糖调节异常； (2)评估胰岛素分泌的阶段； (3) 测定静息代谢率、葡萄糖产热后， 底物氧化及其与身体脂肪分布的关系。