STRUCTURAL ANALYSIS OF HIP BONE MINERAL IMAGE DATA

骨骼结构强度的降低是导致 老年骨质疏松性髋部骨折。而骨矿物质 分析方法被广泛应用于骨折倾向评估 对于易感人群，常规分析不足以 区别对待那些处于危险之中的人。我们已经开发出一种替代方案 一种基于单平面弯曲应力分析的技术 股骨颈，单腿姿势。这项工作不同于 之前的这些努力是因为它使用获得的数据 通过广泛可用的传统骨矿扫描系统。 此外，股骨颈的必要结构特性 是直接从数字骨矿图像数据计算的，具有 一个简单的用户交互程序。除了……之外 考虑差异的结构几何、强度指标 在加载和龄期变化的材料强度，也是 计算出来的。初步工作表明，结构几何学 可以通过以下方法和强度估计可靠地获得 身体股骨与实验测量的相关性更好 强度比传统的骨矿密度要高。这 调查将旨在确定内在的 该方法的物理和生物力学限制，以及 将其敏感性和选择性与常规骨进行比较 矿物质分析，在病人和身体标本中。 物理限制将通过计算机模型进行检查 扫描仪系统，结合了系统几何结构、采样 考虑因素、源发射光谱和组织衰减 属性。其次，对患者进行全面调查 将进行几何测量的定位误差 有一个逼真的臀部幻影。第三，《公约》的有效性 单平面弯曲应力分析将通过 与使用髋关节图像数据的有限元分析进行比较。 这些努力的结果将用于完善 临床实施的方法学。适用于病人 人们将从对侧的检查开始 急性骨质疏松性髋部骨折受试者的髋关节。在一个更大的 规模努力，髋骨矿物质数据来自几个无关的，在- 正在进行的有关骨质疏松症的研究将提供给髋关节 强度分析。这些研究包括：来自 巴尔的摩关于年龄的纵向样本，研究对象来自两个 不同研究下的绝经后妇女不同 治疗方案，以及研究的偏瘫和四肢瘫痪受试者 连续创伤后，或长期瘫痪。

Reduction of skeletal structural strength is a prime cause of osteoporotic hip fractures among the elderly. While bone mineral analysis is widely used in assessment of fracture propensity in susceptible populations, conventional analyses do not adequately discriminate those at risk. We have developed an alternative technique based on a single plane bending stress analysis of the femoral neck, in a one legged stance. The work differs from previous efforts along these lines in that it uses data acquired by widely available, conventional bone mineral scanner systems. Moreover, the necessary structural properties of the femoral neck are computed directly from digital bone mineral image data, with an uncomplicated user interactive program. In addition to structural geometry, strength indices incorporating differences in loading and age changes in material strength, are also computed. Preliminary work indicates that structural geometry may be reliably obtained by the method and strength estimates for cadaver femora correlate better with experimentally measured strength than does conventional bone mineral density. This investigation will be designed to determine the intrinsic physical and biomechanical limitations of the method, and to compare its sensitivity and selectively to conventional bone mineral analysis, in both patients and cadaver specimens. Physical limitations will be examined with a computer model of the scanner system, incorporating system geometry, sampling considerations, source emission spectra and tissue attenuation properties. Secondly, a thorough investigation of patient positioning error on geometric measurements will be conducted with a realistic hip phantom. Thirdly, the validity of the single plane bending stress analysis will be evaluated by comparison with finite element analyses using hip image data. Results of these efforts will be used for refinement of the methodology for clinical implementation. Application to patient populations will begin with an examination of the contralateral hip of acute osteoporotic hip fracture subjects. In a larger scale effort, hip bone mineral data from several unrelated, on- going studies dealing with osteoporosis will be supplied for hip strength analysis. These studies include: subjects from the Baltimore Longitudinal Sample on Aging, subjects from two different studies of postmenopausal women under different treatment regimens, and para- and quadriplegic subjects studied serially post trauma, or with long standing paralysis.