PRECHRONIC AND CHRONIC STUDIES OF GLYOXAL

这些研究将描述毒性和致癌潜力 F344大鼠和B6C3F1小鼠与暴露于乙二醛相关， 饮用水 慢性前毒性将通过给予 乙二醛在五种不同浓度下持续13周。 结束时 将测定研究器官重量，所有动物将接受 完整的大体检查。 所有组织的组织学评价 将进行大体病变和靶器官的检查。 乙二醛的致癌潜力将通过给予 三种不同浓度的乙二醛对F344大鼠的饮水影响 和B6C3F1小鼠2年。 在研究结束时，所有动物将 接受完整的大体检查，所有组织将保存固定， 幻灯片制作 高剂量组所有组织的组织学评价， 对照组动物和低剂量组动物的靶组织中， 进行。

These studies will characterize the toxicity and carcinogenic potential F344 rats and B6C3F1 mice associated with exposure to glyoxal in the drinking water. Prechronic toxicity will be evaluated by administering glyoxal at five different concentrations for 13 weeks. At the end of the study organ weights will be determined and all animals will receive a complete gross examination. Histopathological evaluation of all tissues with gross lesions and of target organs will be done. The carcinogenic potential of glyoxal will be evaluated by administering glyoxal at three different concentrations in drinking eater to F344 rats and B6C3F1 mice for 2 years. At the end of the study all animals will receive a complete gross examination, all tissues will be saved fixed, and slides made. Histopathologic evaluation of all tissues in high dose and control animals and in target tissues in lower dose animals will be conducted.