TOXIC/CARCINOGENIC POTENTIAL OF SELECTED CHEMICALS

选定化学品的有毒/致癌潜力

• 批准号: 6195422
• 负责人: J D PREJEAN
• 金额: $ 18.36万
• 依托单位: SOUTHERN RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-15 至 2000-04-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6195422
• 关键词: carcinogen testing; environmental toxicology; laboratory mouse; laboratory rat; nitrobenzene; organic chemicals; toluene; toxicant screening

The purpose of this project, entitled "Conduct of Studies to Evaluate the Toxicological and Carcinogenic Potential of Selected Chemicals - Riddelline, o-Nitrotoluene, m-Nitrotoluene, p-Nitrotoluene, 2,4- Decadienal, and 2,4-Hexadienal in Laboratory Animals", is to provide for the testing of these six chemicals for the NTP Program. The objective is to continue to characterize the toxicologic effects of chemical and physical substance through studies in animals. The typical approach is repeated administration of the agent to groups of animals for variable periods up to two years or more with clinical, toxicologic and pathologic evaluation of the adverse health effects by comparison with groups of control animals. The second phase of this contract, following the developmental efforts in the base contract, will involve the actual conduct of the prechronic and chronic toxicity/carcinogenicity studies.

这项名为“进行研究以评估 选定化学品的毒理和致癌潜力- 雷德林，邻硝基甲苯，间硝基甲苯，对硝基甲苯，2，4- 实验动物中的十二烯和2，4-己二烯“，是为了 NTP计划对这六种化学物质的测试。我们的目标是 继续描述化学和化学物质的毒理效应 通过在动物身上的研究而产生的物质。典型的方法是 反复给药剂用于动物群体的变数 临床、毒理学和病理学病史长达两年或更长时间 通过与不同人群的比较，评估其对健康的不良影响 控制动物。 本合同的第二阶段，在开发努力之后 在基础合同中，将涉及前期的实际行为 和慢性毒性/致癌性研究。