TOXIC/CARCINOGENIC POTENTIAL OF SELECTED CHEMICALS

选定化学品的有毒/致癌潜力

• 批准号: 6316178
• 负责人: J D PREJEAN
• 金额: --
• 依托单位: SOUTHERN RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-15 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6316178
• 关键词: carcinogen testing; environmental toxicology; laboratory mouse; laboratory rat; nitrobenzene; organic chemicals; toluene; toxicant screening

The purpose of this project, entitled "Conduct of Studies to Evaluate the Toxicological and Carcinogenic Potential of Selected Chemicals - Riddelline, o-Nitrotoluene, m-Nitrotoluene, p-Nitrotoluene, 2,4- Decadienal, and 2,4-Hexadienal in Laboratory Animals", is to provide for the testing of these six chemicals for the NTP Program. The objective is to continue to characterize the toxicologic effects of chemical and physical substance through studies in animals. The typical approach is repeated administration of the agent to groups of animals for variable periods up to two years or more with clinical, toxicologic and pathologic evaluation of the adverse health effects by comparison with groups of control animals. The second phase of this contract, following the developmental efforts in the base contract, will involve the actual conduct of the prechronic and chronic toxicity/carcinogenicity studies.

该项目题为“开展研究， 选定化学品的毒理学和致癌潜力- Riddelline，邻硝基甲苯，间硝基甲苯，对硝基甲苯，2，4- 实验室动物中的癸二烯醛和2，4-己二烯醛”， 这六种化学物质的测试目标是 继续描述化学品的毒理学效应， 通过在动物身上的研究。典型的方法是 对动物组重复施用药剂， 在临床、毒理学和病理学方面， 通过与下列群体的比较评估对健康的不利影响： 对照动物。 该合同的第二阶段，在发展努力之后， 在基础合同中，将涉及预慢性的实际行为 和慢性毒性/致癌性研究。