TOXIC/CARCINOGENIC POTENTIAL OF SELECTED CHEMICALS

选定化学品的有毒/致癌潜力

• 批准号: 6127611
• 负责人: J D PREJEAN
• 金额: $ 50.31万
• 依托单位: SOUTHERN RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-15 至 2000-04-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6127611
• 关键词: carcinogen testing; environmental toxicology; laboratory mouse; laboratory rat; nitrobenzene; organic chemicals; toluene; toxicant screening

The purpose of this project, entitled "Conduct of Studies to Evaluate the Toxicological and Carcinogenic Potential of Selected Chemicals - Riddelline, o-Nitrotoluene, m-Nitrotoluene, p-Nitrotoluene, 2,4- Decadienal, and 2,4-Hexadienal in Laboratory Animals", is to provide for the testing of these six chemicals for the NTP Program. The objective is to continue to characterize the toxicologic effects of chemical and physical substance through studies in animals. The typical approach is repeated administration of the agent to groups of animals for variable periods up to two years or more with clinical, toxicologic and pathologic evaluation of the adverse health effects by comparison with groups of control animals. The second phase of this contract, following the developmental efforts in the base contract, will involve the actual conduct of the prechronic and chronic toxicity/carcinogenicity studies.

该项目的目的，题为“开展研究以评估