MEMORY MECHANISMS IN AGING AND EARLY DEMENTIA

衰老和早期痴呆症的记忆机制

• 批准号: 3767941
• 负责人: HERMAN BUSCHKE
• 金额: --
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3767941
• 关键词: aging; attention; brain disorder diagnosis; cognition disorders; cues; dementia; diagnosis design /evaluation; disease /disorder classification; early diagnosis; human subject; human very old age (85+); interview; learning disorders; longitudinal human study; memory disorders; neural information processing; neuropsychological tests; performance; questionnaires

Dementia is a serious medical, public health and social problem that requires criteria for early identification by differentiating between early dementia memory impairment (EDMI) and age-associated memory impairment (AAMI). Long-term objectives are to study mechanisms of memory impairment in AAMI and EDMI and validate clinical criteria for EDMI and AAMI. Specific aims are to (1) identify EDMI by discrepancy between predicted and observed memory in the ICR Double Memory Test, (2) assess the changes of memory and other cognitive abilities in AAMI and EDMI, (3) account for memory changes in AAMI and EDMI by impairment of specific cognitive processes, and (4) validate criteria for EDMI and AAMI by repeated assessment in long-term follow-up. Specific hypotheses are that EDMI can be differentiated from AAMI by performance scores on the Category ICR memory test that are significantly lower than predicted from performance on the Item ICR memory test; that AAMI can be identified by changes reported in the memory and cognitive history (MacHistory) that result in more frequent memory lapses which are still qualitatively similar to those of young adults; that EDMI can be discriminated from AAMI by changes reported in the MacHistory which are qualitatively as well as quantitatively different from those in AAMI; that criteria for AAMI and EDMI can be enhanced by information from the MacHistory about changes in personal memory and kinds of memory lapses in the real world. Regression analyses will be done to explain changes in AAMI and EDMI by changes of specific cognitive processes in tests of attention, processing capacity, cognitive speed, serial-order learning, and forgetting. The results will provide information needed for more specific earlier diagnosis of AAMI and EDMI, for pharmacologic testing and treatment, and to correlate changes in AAMI and EDMI with physiologic, biochemical and pathologic changes in aging.

痴呆症是一个严重的医疗、公共卫生和社会问题， 要求通过区分早期和早期的 痴呆性记忆障碍和年龄相关性记忆障碍 （AAMI）。 长期目标是研究记忆障碍的机制 在AAMI和EQUIPMENT中，并验证EQUIPMENT和AAMI的临床标准。 具体目标是：（1）通过预测值与 在ICR双重记忆测试中观察到的记忆，（2）评估 记忆和其他认知能力，（3）解释了 特定认知功能损害导致AAMI和Ehrman的记忆变化 过程，以及（4）通过重复验证EQUIPMENT和AAMI的标准 长期随访评估。 具体的假设是， 通过ICR类别的性能评分与AAMI区分 记忆测试，显着低于预测的性能 项ICR存储器测试; AAMI可通过报告变更识别 在记忆和认知史（MacHistory）中， 频繁的记忆缺失，这仍然是定性类似于那些 年轻人;根据报告的变化，Eclampus可与AAMI区分开来 在MacHistory中，定性和定量地 与AAMI中的标准不同; AAMI和ECONDITION的标准可以是 通过MacHistory中有关个人信息变化的信息， 在真实的世界中，记忆和各种记忆会消失。 回归分析 将通过特定的变更来解释AAMI和EQUIPMENT的变更 注意力测试中的认知过程，处理能力， 速度、顺序学习和遗忘。 结果将提供 更具体地早期诊断AAMI和EAE所需的信息， 用于药理学检测和治疗，并与AAMI变化相关 与衰老的生理、生化和病理变化有关。