MEMORY MECHANISMS IN AGING AND EARLY DEMENTIA

痴呆症是一个严重的医学、公共卫生和社会问题， 需要通过区分早期和早期识别的标准 痴呆症记忆障碍(EDMI)与年龄相关性记忆障碍 (AAMI)。长期目标是研究记忆损伤的机制 并验证急性心肌梗死和急性心肌梗死的临床诊断标准。 具体目标是(1)通过预测和预测之间的差异来识别EDMI 在ICR双记忆测验中观察到的记忆，(2)评估 AAMI和EDMI的记忆和其他认知能力，(3)解释了 特定认知功能障碍对急性心肌梗死和老年痴呆患者记忆的影响 流程，以及(4)通过重复验证EDMI和AAMI的标准 长期随访中的评估。具体的假设是EDMI可以 通过ICR类别的表现分数与AAMI区分开来 性能显著低于预期的内存测试 项ICR存储器测试；可以通过报告变化来识别AAMI 在记忆和认知史(MacHistory)中，导致更多 频繁的记忆丧失，在性质上仍与 年轻人；根据报告的变化可以区分EDMI和AAMI 在MacHistory中，无论是定性的还是定量的 不同于AAMI中那些；AAMI和EDMI的标准可以是 来自MacHistory的有关个人信息变化的信息增强了功能 在现实世界中，记忆和各种记忆都会消失。回归分析 将通过特定的变化来解释AAMI和EDMI的变化 注意力、加工能力、认知能力测试中的认知过程 速度、连续顺序学习和遗忘。结果将提供 更具体的急性心肌梗死和急性心肌梗死早期诊断所需的信息， 用于药理学测试和治疗，并与急性心肌梗死的变化相关 衰老过程中的生理、生化和病理改变。

Dementia is a serious medical, public health and social problem that requires criteria for early identification by differentiating between early dementia memory impairment (EDMI) and age-associated memory impairment (AAMI). Long-term objectives are to study mechanisms of memory impairment in AAMI and EDMI and validate clinical criteria for EDMI and AAMI. Specific aims are to (1) identify EDMI by discrepancy between predicted and observed memory in the ICR Double Memory Test, (2) assess the changes of memory and other cognitive abilities in AAMI and EDMI, (3) account for memory changes in AAMI and EDMI by impairment of specific cognitive processes, and (4) validate criteria for EDMI and AAMI by repeated assessment in long-term follow-up. Specific hypotheses are that EDMI can be differentiated from AAMI by performance scores on the Category ICR memory test that are significantly lower than predicted from performance on the Item ICR memory test; that AAMI can be identified by changes reported in the memory and cognitive history (MacHistory) that result in more frequent memory lapses which are still qualitatively similar to those of young adults; that EDMI can be discriminated from AAMI by changes reported in the MacHistory which are qualitatively as well as quantitatively different from those in AAMI; that criteria for AAMI and EDMI can be enhanced by information from the MacHistory about changes in personal memory and kinds of memory lapses in the real world. Regression analyses will be done to explain changes in AAMI and EDMI by changes of specific cognitive processes in tests of attention, processing capacity, cognitive speed, serial-order learning, and forgetting. The results will provide information needed for more specific earlier diagnosis of AAMI and EDMI, for pharmacologic testing and treatment, and to correlate changes in AAMI and EDMI with physiologic, biochemical and pathologic changes in aging.