MEMORY MECHANISMS IN AGING AND EARLY DEMENTIA
MEMORY MECHANISMS IN AGING AND EARLY DEMENTIA
批准号:
3767941
负责人:
HERMAN BUSCHKE
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
aging attention brain disorder diagnosis cognition disorders cues dementia diagnosis design /evaluation disease /disorder classification early diagnosis human subject human very old age (85+) interview learning disorders longitudinal human study memory disorders neural information processing neuropsychological tests performance questionnaires
中文摘要
痴呆症是一个严重的医学、公共卫生和社会问题,
需要通过区分早期和早期识别的标准
痴呆症记忆障碍(EDMI)与年龄相关性记忆障碍
(AAMI)。长期目标是研究记忆损伤的机制
并验证急性心肌梗死和急性心肌梗死的临床诊断标准。
具体目标是(1)通过预测和预测之间的差异来识别EDMI
在ICR双记忆测验中观察到的记忆,(2)评估
AAMI和EDMI的记忆和其他认知能力,(3)解释了
特定认知功能障碍对急性心肌梗死和老年痴呆患者记忆的影响
流程,以及(4)通过重复验证EDMI和AAMI的标准
长期随访中的评估。具体的假设是EDMI可以
通过ICR类别的表现分数与AAMI区分开来
性能显著低于预期的内存测试
项ICR存储器测试;可以通过报告变化来识别AAMI
在记忆和认知史(MacHistory)中,导致更多
频繁的记忆丧失,在性质上仍与
年轻人;根据报告的变化可以区分EDMI和AAMI
在MacHistory中,无论是定性的还是定量的
不同于AAMI中那些;AAMI和EDMI的标准可以是
来自MacHistory的有关个人信息变化的信息增强了功能
在现实世界中,记忆和各种记忆都会消失。回归分析
将通过特定的变化来解释AAMI和EDMI的变化
注意力、加工能力、认知能力测试中的认知过程
速度、连续顺序学习和遗忘。结果将提供
更具体的急性心肌梗死和急性心肌梗死早期诊断所需的信息,
用于药理学测试和治疗,并与急性心肌梗死的变化相关
衰老过程中的生理、生化和病理改变。
英文摘要
Dementia is a serious medical, public health and social problem that
requires criteria for early identification by differentiating between early
dementia memory impairment (EDMI) and age-associated memory impairment
(AAMI). Long-term objectives are to study mechanisms of memory impairment
in AAMI and EDMI and validate clinical criteria for EDMI and AAMI.
Specific aims are to (1) identify EDMI by discrepancy between predicted and
observed memory in the ICR Double Memory Test, (2) assess the changes of
memory and other cognitive abilities in AAMI and EDMI, (3) account for
memory changes in AAMI and EDMI by impairment of specific cognitive
processes, and (4) validate criteria for EDMI and AAMI by repeated
assessment in long-term follow-up. Specific hypotheses are that EDMI can
be differentiated from AAMI by performance scores on the Category ICR
memory test that are significantly lower than predicted from performance on
the Item ICR memory test; that AAMI can be identified by changes reported
in the memory and cognitive history (MacHistory) that result in more
frequent memory lapses which are still qualitatively similar to those of
young adults; that EDMI can be discriminated from AAMI by changes reported
in the MacHistory which are qualitatively as well as quantitatively
different from those in AAMI; that criteria for AAMI and EDMI can be
enhanced by information from the MacHistory about changes in personal
memory and kinds of memory lapses in the real world. Regression analyses
will be done to explain changes in AAMI and EDMI by changes of specific
cognitive processes in tests of attention, processing capacity, cognitive
speed, serial-order learning, and forgetting. The results will provide
information needed for more specific earlier diagnosis of AAMI and EDMI,
for pharmacologic testing and treatment, and to correlate changes in AAMI
and EDMI with physiologic, biochemical and pathologic changes in aging.
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会议论文
MEMORY MECHANISMS OF AGING, PRECLINICAL AND EARLY DEMENTIA
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批准号:6816979
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项目类别:
-
资助金额:$39.91万
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财政年份:2004
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负责人:HERMAN BUSCHKE
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依托单位:
MEMORY MECHANISMS IN AGING, PRECLINICAL AND EARLY DEMENTIA
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批准号:6324493
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项目类别:
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资助金额:$27.09万
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财政年份:2000
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负责人:HERMAN BUSCHKE
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依托单位:
MEMORY MECHANISMS IN AGING, PRECLINICAL AND EARLY DEMENTIA
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批准号:6097945
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项目类别:
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资助金额:$27.09万
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财政年份:1999
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负责人:HERMAN BUSCHKE
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依托单位:
MEMORY MECHANISMS IN AGING, PRECLINICAL AND EARLY DEMENTIA
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批准号:6267193
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项目类别:
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资助金额:$27.19万
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财政年份:1998
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负责人:HERMAN BUSCHKE
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依托单位:
MEMORY AND COGNITION IN ALZHEIMER'S DISEASE AND AGING
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批准号:3115266
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项目类别:
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资助金额:$17.18万
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财政年份:1984
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负责人:HERMAN BUSCHKE
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依托单位:
MEMORY AND COGNITION IN ALZHEIMER'S DISEASE AND AGING
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批准号:3115267
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项目类别:
-
资助金额:$17.64万
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财政年份:1984
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负责人:HERMAN BUSCHKE
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依托单位:
MEMORY AND COGNITION IN ALZHEIMER'S DISEASE AND AGING
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批准号:3115263
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项目类别:
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资助金额:$16.87万
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财政年份:1984
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负责人:HERMAN BUSCHKE
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依托单位:
RETRIEVAL AND CLUSTERING IN DEVELOPMENT OF LEARNING
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批准号:4697015
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:HERMAN BUSCHKE
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依托单位:
MEMORY MECHANISMS OF AGING, PRECLINICAL AND EARLY DEMENTIA
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批准号:7087670
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项目类别:
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资助金额:$38.33万
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财政年份:--
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负责人:HERMAN BUSCHKE
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依托单位:
MEMORY MECHANISMS IN AGING AND EARLY DEMENTIA
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批准号:3726188
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:HERMAN BUSCHKE
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依托单位:
MEMORY MECHANISMS IN AGING AND EARLY DEMENTIA
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批准号:3745626
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:HERMAN BUSCHKE
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依托单位:
MEMORY MECHANISMS OF AGING, PRECLINICAL AND EARLY DEMENTIA
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批准号:7463634
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项目类别:
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资助金额:$44.91万
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财政年份:--
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负责人:HERMAN BUSCHKE
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依托单位:
MEMORY MECHANISMS OF AGING, PRECLINICAL AND EARLY DEMENTIA
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批准号:7255667
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项目类别:
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资助金额:$39.13万
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财政年份:--
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负责人:HERMAN BUSCHKE
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依托单位:
MEMORY MECHANISMS IN AGING AND EARLY DEMENTIA
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批准号:3789948
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:HERMAN BUSCHKE
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依托单位:
MEMORY MECHANISMS OF AGING, PRECLINICAL AND EARLY DEMENTIA
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批准号:7637322
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项目类别:
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资助金额:$48.86万
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财政年份:--
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负责人:HERMAN BUSCHKE
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依托单位:
国内基金
海外基金
多模态超声VisTran-Attention网络评估早期子宫颈癌保留生育功能手术可行性
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批准号:--
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项目类别:青年科学基金项目
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资助金额:30万元
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批准年份:2022
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负责人:郑巧
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依托单位:
Ultrasomics-Attention孪生网络早期精准评估肝内胆管癌免疫治疗的研究
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批准号:--
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项目类别:面上项目
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资助金额:52万元
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批准年份:2022
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负责人:陈立达
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依托单位: