Control of insulin secretion by Y1 receptor signalling

Y1 受体信号传导控制胰岛素分泌

• 批准号: nhmrc : GNT1144286
• 负责人: A/Pr David Laybutt
• 金额: $ 67.56万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/control-insulin-secretion-receptor-signalling/1348601
• 关键词: Control; insulin; secretion; Y1; receptor

Diabetes is the most common metabolic disease worldwide. Impaired insulin secretion and beta cell function is one of its major causes. We have recently discovered a key signaling pathway that we believe hold the secret to inhibiting insulin secretion in beta cells and blocking it leads to significant insulin release. This proposal focuses on this pathway and its regulation using innovative and unique tools. This will provide a novel treatment option for diabetes as well as islet transplantation.

糖尿病是世界范围内最常见的代谢性疾病。胰岛素分泌和β细胞功能受损是其主要原因之一。我们最近发现了一个关键的信号通路，我们认为它是抑制β细胞胰岛素分泌的秘密，阻断它会导致显著的胰岛素释放。该提案侧重于这一途径及其使用创新和独特工具的监管。这将为糖尿病和胰岛移植提供一种新的治疗选择。