Mechanisms of beta-cell dysfunction in diabetes

糖尿病β细胞功能障碍的机制

• 批准号: nhmrc : 1030715
• 负责人: A/Pr David Laybutt
• 金额: $ 47.61万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-beta-cell-dysfunction-diabetes/110770
• 关键词: Mechanisms; beta; cell; dysfunction; diabetes

Type 2 diabetes is a health crisis in Australia. In this project, we will investigate the mechanisms whereby high glucose and fat impair pancreatic beta-cell function leading to type 2 diabetes. We will establish how endoplasmic reticulum stress and the protein Id1 are linked with loss of beta-cell gene expression and function. The information gained will further our understanding of the basic mechanisms regulating insulin secretion and provide new therapeutic targets for diabetes treatment.

2型糖尿病在澳大利亚是一种健康危机。在这个项目中，我们将研究高糖和高脂肪损害胰腺β细胞功能导致2型糖尿病的机制。我们将确定内质网应激和蛋白质Id 1如何与β细胞基因表达和功能丧失相关。所获得的信息将进一步加深我们对调节胰岛素分泌的基本机制的理解，并为糖尿病治疗提供新的治疗靶点。