Mechanisms of beta-cell dysfunction in diabetes

2型糖尿病是澳大利亚的健康危机。在这个项目中，我们将研究高糖和高脂肪损害胰腺β细胞功能导致2型糖尿病的机制。我们将确定内质网应激和蛋白质Id1如何与β细胞基因表达和功能的丧失相关联。这些信息将进一步加深我们对调节胰岛素分泌的基本机制的理解，并为糖尿病的治疗提供新的治疗靶点。

Type 2 diabetes is a health crisis in Australia. In this project, we will investigate the mechanisms whereby high glucose and fat impair pancreatic beta-cell function leading to type 2 diabetes. We will establish how endoplasmic reticulum stress and the protein Id1 are linked with loss of beta-cell gene expression and function. The information gained will further our understanding of the basic mechanisms regulating insulin secretion and provide new therapeutic targets for diabetes treatment.