Role of the adaptive unfolded protein response in beta-cell compensation
Role of the adaptive unfolded protein response in beta-cell compensation
批准号:
nhmrc : 1069511
负责人:
A/Pr David Laybutt
金额:
$38.79万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2017-12-31
中文摘要
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英文摘要
Obesity is a strong risk factor for type 2 diabetes. Obese subjects with “robust” pancreatic beta-cells can sustain a compensatory response. Type 2 diabetes arises in subjects with beta-cells that are “susceptible” to dysfunction and death. We will investigate the role of the adaptive unfolded protein response in beta-cell compensation for obesity-associated insulin resistance. Findings will help explain why some individuals but not others develop type 2 diabetes.
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New molecular mechanisms of islet protection against diabetes
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批准号:nhmrc : 1144206
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项目类别:Project Grants
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资助金额:$45.52万
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财政年份:2018
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负责人:A/Pr David Laybutt
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依托单位:
New molecular mechanisms of islet protection against diabetes
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批准号:nhmrc : GNT1144206
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项目类别:Project Grants
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资助金额:$67.33万
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财政年份:2018
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负责人:A/Pr David Laybutt
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依托单位:
Control of insulin secretion by Y1 receptor signalling
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批准号:nhmrc : 1144286
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项目类别:Project Grants
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资助金额:$45.68万
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财政年份:2018
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负责人:A/Pr David Laybutt
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依托单位:
Control of insulin secretion by Y1 receptor signalling
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批准号:nhmrc : GNT1144286
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项目类别:Project Grants
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资助金额:$67.56万
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财政年份:2018
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负责人:A/Pr David Laybutt
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依托单位:
Mechanisms of beta-cell compensation
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批准号:nhmrc : GNT1069511
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项目类别:Project Grants
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资助金额:$56.26万
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财政年份:2014
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负责人:A/Pr David Laybutt
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依托单位:
Mechanisms of beta-cell dysfunction in diabetes
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批准号:nhmrc : 1030715
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项目类别:Project Grants
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资助金额:$47.61万
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财政年份:2012
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负责人:A/Pr David Laybutt
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依托单位:
Beta cell mass in Type 1 diabetes mellitus and islet transplantation
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批准号:nhmrc : 427695
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项目类别:NHMRC Strategic Awards
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资助金额:$204.72万
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财政年份:2008
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负责人:A/Pr David Laybutt
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依托单位:
Mechanisms of beta-cell failure in diabetes
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批准号:nhmrc : 427616
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项目类别:NHMRC Project Grants
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资助金额:$35.81万
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财政年份:2007
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负责人:A/Pr David Laybutt
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依托单位:
Mechanisms of fatty-acid mediated destruction of pancreatic beta cells
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批准号:nhmrc : 376020
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项目类别:NHMRC Project Grants
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资助金额:$34.04万
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财政年份:2006
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负责人:A/Pr David Laybutt
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依托单位:
Pancreatic beta-cell dysfunction in diabetes
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批准号:nhmrc : 325618
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项目类别:NHMRC Project Grants
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资助金额:$25.96万
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财政年份:2005
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负责人:A/Pr David Laybutt
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依托单位:
Islet B-cell growth, differentiation and function in typpw 2 diabetes:
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批准号:nhmrc : 188829
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项目类别:Career Development Fellowships
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资助金额:$28.34万
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财政年份:2002
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负责人:A/Pr David Laybutt
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依托单位:
国内基金
海外基金
下一代无线通信系统自适应调制技术及跨层设计研究
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批准号:60802033
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项目类别:青年科学基金项目
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资助金额:16.0万元
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批准年份:2008
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负责人:刘凯明
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依托单位:
由蝙蝠耳轮和鼻叶推导新型仿生自适应波束模型的研究
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批准号:10774092
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项目类别:面上项目
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资助金额:39.0万元
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批准年份:2007
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负责人:Rolf Mueller
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依托单位: