Role of the adaptive unfolded protein response in beta-cell compensation

适应性未折叠蛋白反应在β细胞补偿中的作用

• 批准号: nhmrc : 1069511
• 负责人: A/Pr David Laybutt
• 金额: $ 38.79万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-adaptive-unfolded-cell-compensation/455399
• 关键词: Role; adaptive; unfolded; protein; response

Obesity is a strong risk factor for type 2 diabetes. Obese subjects with “robust” pancreatic beta-cells can sustain a compensatory response. Type 2 diabetes arises in subjects with beta-cells that are “susceptible” to dysfunction and death. We will investigate the role of the adaptive unfolded protein response in beta-cell compensation for obesity-associated insulin resistance. Findings will help explain why some individuals but not others develop type 2 diabetes.

肥胖是2型糖尿病的一个重要危险因素。具有“强健”胰腺β细胞的肥胖受试者可以维持代偿反应。2型糖尿病发生在具有对功能障碍和死亡“敏感”的β细胞的受试者中。我们将研究适应性未折叠蛋白反应在β细胞补偿肥胖相关胰岛素抵抗中的作用。研究结果将有助于解释为什么有些人而不是其他人患上2型糖尿病。