SUBCHRONIC AND CHRONIC DOSED WATER STUDIES OF PYRIDINE

吡啶的亚慢性和慢性定量水研究

• 批准号: 2311601
• 负责人: ANDREW BRAUN
• 金额: $ 34.12万
• 依托单位: TSI MASON LABORATORIES
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-06-30 至 1994-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2311601
• 关键词: pyridine; toxin metabolism

Pyridine is used as a solvent for anhydrous mineral salts, in organic synthesis, in analytical chemistry, and in the manufacturing of fungicides, vitamins, drugs, disinfectants, and dyes. Pyridine is also used in flavoring ingredients, in non-alcoholic beverages, ice cream, candy and baked goods. Because of the widespread use of pyridine there is potential for exposure both in the workplace and in the home. There is relatively little information on the potential toxicity and carcinogenicity of this chemical. The 13-week toxicity studies of pyridine are currently in progress. F344/N rats, B6C3F1 ice, and Wistar rats are being administered the chemical in the drinking water, and at the end of the dosing period target organ toxicity and general toxicity will be characterized to help in identifying any potential side effects from exposure to pyridine.

吡啶在有机溶剂中用作无水无机盐的溶剂， 合成，分析化学，以及杀真菌剂的生产， 维生素、药物、消毒剂和染料。 吡啶也用于 非酒精饮料、冰淇淋、糖果和 烘焙食品 由于吡啶的广泛使用， 无论是在工作场所还是在家里 存在相对 关于其潜在毒性和致癌性的信息很少 化工有限 吡啶的13周毒性研究目前正在进行中。 F344/N 大鼠，B6 C3 F1冰，和Wistar大鼠被给予化学品， 饮用水，给药期结束时靶器官 毒性和一般毒性的特征，以帮助确定 任何潜在的副作用。