STUDY OF THE LEGACY OF USPHS TUSKEGEE SYPHILIS STUDY

美国公共卫生署（USPHS）细节曝光 “黑人男性未经治疗的梅毒的塔斯基吉梅毒研究” 1972年的全国性报纸经常被认为是最有影响力的单一 直接导致机构审查委员会成立的力量 （IRB）在美国联邦政府资助的 问题研究总的来说，塔斯基吉遗产项目是一个五个阶段， 项目（即由5项连续、相关但独立的研究组成）， 补充性的定性和定量数据收集要素。 的 这一调查的基本概念是“是否和为什么”少数民族 (esp.非裔美国人）不愿意参加生物医学 研究是利用定性数据收集方法（重点 小组调查结果和专家访谈结果），以指导 量化工具（文化敏感问题单）， 允许对非裔美国人的这一主题进行比较研究， 西班牙人和白人第四阶段，如国家人权事务委员会赠款所述 申请将于资助计划的第四年（即一九八八年）开始。 它将 有定量和定性的组成部分，并将 该项目的特点是从东北地区的扩张， 一项针对美国几个选定地区的研究。定性 这一组成部分将包括在这些其他区域进行重点小组讨论， 美国;定量部分将包括最后分析 第三阶段调查问卷数据的解释 这项研究将于一九八八年六月完成。 鉴于最近1994年国家卫生研究院关于妇女和 少数民族的生物医学研究，这个项目对所有的意义 生物医学研究人员。塔斯基吉遗产的第四阶段研究 项目将继续进行一系列调查， 少数民族健康研究项目，一般来说，并为我们的国家人权事务委员会， 特别的。招募足够数量的受试者进入任何临床研究 学习总是具有挑战性的，而且常常是有问题的。这将是 招募非洲裔美国人的问题，如果'几内亚 猪恐惧因素的遗产（不管它是否是，事实上，由于 塔斯基吉研究，或者--由于非洲更广泛的社会现实-- 美国人在过去200年里的生活）。有着显著的影响 非裔美国人与白人的入学态度。本IV期研究 将提供数据，以加强对关键问题的理解， 与招募非裔美国人研究对象有关

The exposure of the details of U.S. Public Health Service (USPHS) 'Tuskegee Syphilis Study on Untreated Syphilis in the Negro Male' in national newspapers in 1972 is often cited as the most influential single force that directly led to the creation of Institutional Review Boards (IRBs) for the protection of human subjects in U.S. federally-funded studies. In its totality, The Tuskegee Legacy Project is a five Phase project (i.e. consists of 5 sequential, related but separate studies) with complementary qualitative and quantitative data collection elements. The basic concept of this investigation into 'whether and why' minorities (esp. African-Americans) are reluctant to participate in biomedical research studies is to utilize qualitative data gathering methods (focus group findings and expert interview findings) to guide the development of a quantitative instrument (a culturally-sensitive questionnaire) that will allow for a comparative study of this topic across African-Americans, Hispanics and Whites. Phase IV, as described in this NMOHRC grant application will be initiate in Year 04 of this grant, i.e. 1988. It will have both quantitative and qualitative components and will be characterized by the expansion of this project from a Northeast Regional study to a study of several selected regions of the U.S.. The qualitative component will consist conducting focus groups in these other regions of the U.S.; the quantitative component will consist of the final analysis and interpretation of the questionnaire data obtained in the Phase Ill study which will be completed by June 1988. Given the recent 1994 NIH guidelines on the inclusion of women and minorities in biomedical research, this project has significance for all biomedical researchers. This Phase IV study within the Tuskegee Legacy Project will continue a line of inquiry that has great relevance for minority health research projects, in general, and for our NMOHRC, in particular. Recruitment of adequate numbers of subjects into any clinical study is always challenging and often problematic. This would be compounded for the recruitment of African-American subjects if the 'guinea pig fear factor' legacy (regardless of whether it is, in fact, due to the Tuskegee Study, or--due to the broader societal realities for African- Americans over the last 200 years in the U.S.) has a measurable impact on enrollment attitudes of African-Americans vs Whites. This Phase IV study will provide data that will enhance understanding of the critical issues related to the recruiting of African-American research subjects.