(Lost-Tfh) Lost in space: How spatial dysregulation of T follicular helper cells impairs vaccine responses in ageing

(Lost-Tfh) 迷失在空间：滤泡辅助 T 细胞的空间失调如何损害衰老过程中的疫苗反应

• 批准号: EP/X022382/1
• 负责人: Michelle Linterman
• 金额: $ 219.62万
• 依托单位: Babraham Institute
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FX022382%2F1
• 关键词: Lost; Tfh; space; How; spatial

A successful response to vaccination requires the cells of the immune system to get together at the right place, and at the right time. We have identified that in older bodies a particular type of white blood cell, helper T cells, does not get to the right place after immunisation. This proposal aims to determine why, and to identify what the consequences are of these lost-helpers for the immune response to vaccination and for the other cell types that they would normally interact with.

对疫苗接种的成功反应需要免疫系统的细胞在正确的地点和正确的时间聚集在一起。我们已经发现，在老年人的身体中，一种特殊类型的白色血细胞，即辅助性T细胞，在免疫后无法到达正确的位置。该提案旨在确定原因，并确定这些失去的助手对疫苗接种的免疫应答以及它们通常会与之相互作用的其他细胞类型的后果。