MULTICENTER AIDS COHORT STUDY

多中心艾滋病队列研究

• 批准号: 2070415
• 负责人: ALFRED J SAAH
• 金额: $ 107.37万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-04-01 至 1999-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2070415
• 关键词: AIDS; AIDS therapy; African American; HIV infections; bisexual; disease /disorder proneness /risk; epidemiology; histocompatibility antigens; homosexuals; human subject; human therapy evaluation; longitudinal human study; male; neuropsychology; nutrition related tag; pathologic process; questionnaires; tissue resource /registry

The Study to Help the AIDS Research Effort (SHARE) was funded in 1983 by the National Institute of Allergy and Infectious Diseases and the National Cancer Institute. From the beginning, the research in Baltimore was closely coordinated with the clinical sites in Pittsburgh, Chicago and Los Angeles. The resulting collaboration between the four clinical sites, investigators at the NIH and the data center became known as the Multicenter AIDS Cohort Study (MACS). The MACS was designed to be a study of the natural history of risk factors for and progression toward AIDS. Shortly after the study began, HIV (known then as HTLV-III/LAV) was discovered, thus making the study a natural history study of HIV infection. Participants have been seen at least every six months since enrollment began in April 1984. An interviewer-administered questionnaire and a focused physical examination have been performed at each clinical visit. Specimens (including serum, plasma, and cryopreserved peripheral blood mononuclear cells) have been collected at each visit and stored in both national and local repositories. The initial cohort in SHARE consisted of 1,153 gay/bisexual men who were recruited from April to October 1984. Of these, 30% were HIV seropositive at baseline and 104 of the baseline seronegative participants seroconverted. Recruitment was reopened in 1987 in order to recruit partners of current participants and minority gay men. Two hundred forty more participants joined the study, half of whom are African Americans. The prevalence of infection in the newly recruited cohort was 50% at baseline. From the natural history studies in the MACS, we have learned risk factors for infection and the natural history of untreated and treated HIV infection. Immunological, virological, HLA-associated and behavioral factors that may be associated with prolonged or shortened duration of HIV infection are being hotly pursued MACS-wide and in collaboration with investigators from many different institutions. Research into the virological and immunopathological mechanisms of progressive HIV infection are vital areas to be addressed in other applications. This application provides the support for the infrastructure to continue the clinical and epidemiological follow-up of the cohort and to facilitate collaboration with bench scientists both inside and outside of the MACS. A complete description of the clinical spectrum of HIV-associated disorders is also an important area of research for the future. This research will include: epidemiological, nutritional and behavioral factors associated with prolonged survival, and continuing the neuropsychological studies to accurately describe the treated and untreated natural history of these disorders in HIV infection. Therefore, follow-up of cohort members for important post-AIDS outcomes, such as all HIV-related infections, other infections, malignancies, and neuropsychological events and survival is become a primary focus of the study.

帮助艾滋病研究工作的研究（SHARE）于1983年由 国家过敏和传染病研究所和国家 癌症研究所.从一开始，在巴尔的摩的研究就是 与匹兹堡、芝加哥和洛杉矶的临床研究中心密切协调 洛杉矶。四个临床研究中心之间的合作， 美国国立卫生研究院和数据中心的研究人员被称为 多中心艾滋病队列研究（MACS）。MACS被设计成一个研究 艾滋病的危险因素和发展的自然史。 研究开始后不久，艾滋病毒（当时称为HTLV-III/LAV） 发现，从而使这项研究成为艾滋病毒的自然史研究 感染从那以后，参与者至少每六个月见一次面。 1984年4月开始招生。一份由采访者填写的问卷 并在每个诊所进行了重点体检 访问标本（包括血清、血浆和冻存外周血 血液单核细胞），并储存在 国家和地方储存库。 SHARE的初始队列由1，153名同性恋/双性恋男性组成，他们是 1984年4月至10月招募。其中30%的人艾滋病毒血清反应呈阳性 104例基线血清阴性受试者 血清转化1987年重新开始招募， 目前参与者的伴侣和少数同性恋男性。二百四十 更多的参与者加入了这项研究，其中一半是非洲裔美国人。 新招募队列的感染率为50%， 基线。从MACS的自然历史研究中，我们了解到 感染的风险因素和未经治疗的自然史， 治疗HIV感染。 免疫学、病毒学、HLA相关和行为因素， 与艾滋病毒感染持续时间延长或缩短有关的是 在整个MACS范围内， 许多不同的机构。研究病毒学和 进行性HIV感染的免疫病理学机制是重要领域 在其他应用中解决。此应用程序提供了 支持基础设施，以继续临床和 流行病学后续行动的队列，并促进合作 与MACS内外的实验室科学家进行了交流 艾滋病毒相关的临床谱的完整描述 疾病也是未来研究的重要领域。这 研究将包括：流行病学、营养和行为因素 与延长生存期相关，并继续神经心理学 准确描述治疗和未治疗自然史的研究 艾滋病病毒感染中的这些疾病。因此，队列随访 艾滋病后的重要成果，如所有与艾滋病毒有关的 感染、其他感染、恶性肿瘤和神经心理事件 存活率成为研究的主要焦点。