NATURAL HISTORY OF HIV-1 INFECTION IN HOMOSEXUAL AND BISEXUAL MEN

同性恋和双性恋男性 HIV-1 感染的自然史

• 批准号: 6245355
• 负责人: ALFRED J SAAH
• 金额: $ 2.23万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-05 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6245355
• 关键词: HIV infections; T lymphocyte; bisexual; clinical research; homosexuals; human subject; leukocyte count; longitudinal human study; male; neuropsychological tests; pathologic process; patient /disease registry; questionnaires

The Study to Help the AIDS Research Effort (SHARE) was funded for an additional four years in 1995. We continue to utilize the OPD-GCRC as the primary source of data collection (blood specimens, physical, and questionnaire. Clinic is held two evenings a week, with special arrangements made for participants who are unable to make regular clinic hours. Long-term substudies (Neuropsychological) and new studies are coordinated in and out of the primary study on a regular basis. Current research focuses on all aspects of HIV infection and progression to disease. Immunologic studies initiated in previous years are continuing and include the investigation of the hypothesis of blind T cell homeostasis which postulates the existence of a physiologic mechanism that maintains constant numbers of T lymphocytes in the peripheral blood. The failure of this mechanism occurs approximately two year's AIDS (clinical definition) on the average. Dr. Joseph Margolick, who heads the MACS pathogenesis laboratory, along with collaborators from other sites, has been studying individual subjects with failure of T cell homeostasis to try to understand the mechanism of this failure. The neuropsychological study has been screening participants since 1987. More than 200 HIV seropositive participants were tested in 1996. In addition, detailed neurological assessments were performed on 46 participants half of these occurred in a special Saturday clinic. This research has provided insights into the effects of HIV infection on neurological function. Adamson, et al., showed that severe HIV dementia was associated with significant elevations in brain levels of immunologic nitric oxide and gp4 1. This study is important because it associates elevations in brain levels of HIV proteins with immunologic activation and may provide important clues to unraveling the pathophysiological mechanism of HIV associated dementia. Dr Alfred Saah, the study principal investigator, has been involved with several research initiatives within the study. These include the investigation of the role of micro nutrients in HIV-1 disease progression and the progression of HIV- I disease in gay men with no access to treatment. He presented data at the XI International Conference on AIDS which showed that the TRAX CD4 Kit ( an EIA test) is an effective method for measuring T- helper counts when compared with the conventional method of flow cytometry. The cohort continues to serve as a resource to investigators who have an interest in studying HIV infection at all stages.

帮助艾滋病研究工作的研究（SHARE）获得了资助， 1995年又增加了四年。 我们继续利用OPD-GCRC， 数据收集的主要来源（血液标本、物理标本和 问卷 诊所每周举行两个晚上，有特殊的 为无法定期就诊的参加者作出安排 小时 长期子研究（神经心理学）和新研究 定期在主要研究中进行协调。 目前的研究集中在艾滋病毒感染和进展的各个方面 疾病。 前几年开始的免疫学研究 继续并包括盲T假设的调查 细胞内稳态，其假设存在生理性的 维持T淋巴细胞数量恒定的机制。 外周血 这种机制的失效大约发生在 艾滋病（临床定义）平均两年。 约瑟夫博士 马戈里克是MACS发病机理实验室的负责人，沿着 来自其他网站的合作者，一直在研究个别科目， T细胞内稳态的失败来试图理解 这一失败。 神经心理学研究自1987年以来一直在筛选参与者。 1996年，200多名艾滋病毒血清呈阳性的参与者接受了检测。 在 此外，对46名患者进行了详细的神经系统评估， 其中一半发生在一个特殊的周六诊所。这 研究提供了深入了解艾滋病毒感染的影响， 神经功能 Adamson等人，表明严重的艾滋病病毒 痴呆症与脑内 免疫一氧化氮和gp 4 1。这项研究很重要，因为它 将脑内HIV蛋白水平的升高与免疫系统 激活，并可能提供重要的线索，解开 HIV相关痴呆的病理生理机制 该研究的主要研究者Alfred Saah博士参与了 研究中的几个研究项目。 其中包括 微量营养素在HIV-1疾病中作用的研究 艾滋病的进展和艾滋病的进展在男同性恋者没有 获得治疗。 他在第十一届国际 艾滋病会议，其中表明，TRAX CD4试剂盒（EIA测试） 是测量辅助性T细胞计数的有效方法， 用流式细胞术的常规方法。 该队列继续作为研究人员的资源， 研究艾滋病毒感染的各个阶段。