MULTICENTER AIDS COHORT STUDY

多中心艾滋病队列研究

• 批准号: 3548169
• 负责人: ALFRED J SAAH
• 金额: $ 244.03万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-04-01 至 1995-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3548169
• 关键词: AIDS; AIDS /HIV test; AIDS therapy; African American; HIV infections; bisexual; clinical trials; disease /disorder proneness /risk; epidemiology; homosexuals; human subject; human therapy evaluation; interview; leukocyte count; longitudinal human study; lymphocyte; male; neuropsychology; nutrition related tag; opportunistic infections; pathologic process; prognosis; questionnaires; tissue resource /registry

The Study to Help the AIDS Research Effort (SHARE) started in 1983 when it was funded by the National Institute of Allergy and Infectious Diseases and the National Cancer Institute. From the beginning, the research in Baltimore was closely coordinated with the clinical sites in Pittsburgh, Chicago and Los Angeles. The resulting collaboration between the four clinical sites, investigators at the NIH and the data center became known as the Multicenter AIDS Cohort Study (MACS). The MACS was designed to be a study of the natural history of risk factors for and progression toward AIDS. Shortly after the study began, HIV (known then as HTLV-III/LAV) was discovered, thus making the study a natural history study of HIV infection. Participants have been seen at least every six months since enrollment began in April 1984. An interviewer-administered questionnaire and a focused physical examination have been conducted at each clinical visit. Specimens (including serum, plasma, and cryopreserved peripheral blood mononuclear cells) have been collected at each visit and stored in both national and local repositories. Semen and feces were collected for the first 12 to 30 months of the study, but are now occasionally collected for special studies. The initial cohort in SHARE consisted of 1,153 gay/bisexual men who were recruited from April to October 1984. Of these, 30% were HIV seropositive at baseline and 95 of those who were seronegative at baseline seroconverted. Recruitment was reopened in 1987 in order to recruit lovers of current participants and minority gay men. Two hundred thirty-one more participants were added as of October 1990. Of these, half are African Americans. The prevalence of infection in the newly recruited cohort was 31 % at baseline. From the natural history studies in the MACS, we have learned the risk factors for infection and the natural history of untreated HIV infection. The MACS has contributed significantly to scientific and public health policy decisions in the U.S. Over the last two years the MACS has moved to studying the natural history of treated HIV infection and factors associated with prolonged or shortened survival with HIV infection or clinical AIDS. Followup of cohort members for important outcomes, such as all HIV-related infections, other infections, malignancies, and neuropsychological events, has become a primary focus of the study. Research into the virological and immunopathological mechanisms of progressive HIV infection are vital areas to be addressed in this proposal. A complete description of the clinical spectrum of HIV- associated disorders is also an important area of research for the future. This research will include: epidemiological, nutritional and behavioral factors associated with prolonged survival, and expansion of the neuropsychological studies to accurately describe the natural history of these disorders in HIV infection.

帮助艾滋病研究工作的研究（SHARE）始于1983年， 由国家过敏和传染病研究所资助 和国家癌症研究所。从一开始， 巴尔的摩与匹兹堡的临床研究中心密切协调， 芝加哥和洛杉矶。四人之间的合作 临床试验机构、NIH的研究人员和数据中心的研究人员 多中心艾滋病队列研究（MACS）MACS被设计成 一项研究的自然历史的风险因素和进展， 艾滋病研究开始后不久，艾滋病毒（当时称为HTLV-III/LAV） 发现，从而使这项研究成为艾滋病毒的自然史研究 感染从那以后，参与者至少每六个月见一次面。 1984年4月开始招生。一份由采访者填写的问卷 并在每个诊所进行了重点体检 访问标本（包括血清、血浆和冻存外周血 血液单核细胞），并储存在 国家和地方储存库。收集精液和粪便， 研究的前12到30个月，但现在偶尔收集 进行特殊研究。 SHARE的初始队列由1，153名同性恋/双性恋男性组成，他们是 1984年4月至10月招募。其中30%的人艾滋病毒血清反应呈阳性 95例基线血清反应阴性的受试者 血清转化1987年重新开始招募，目的是招募情人 现有参与者和少数男同性恋者。还有231个 1990年10月加入。其中一半是非洲人 美国人新招募队列的感染率为 基线时为31%。从MACS的自然历史研究中，我们有 了解了感染的风险因素和自然史， 未经治疗的艾滋病毒感染。MACS为以下方面做出了重大贡献： 美国的科学和公共卫生政策决定。 在过去的两年里，MACS已经开始研究自然历史， 治疗的艾滋病毒感染和与长期或 艾滋病毒感染或临床艾滋病的生存期缩短。队列随访 重要成果，如所有与艾滋病毒有关的感染，其他 感染，恶性肿瘤和神经心理事件，已成为一个 研究的主要焦点。 研究的病毒学和免疫病理学机制 进行性艾滋病毒感染是这方面需要解决的重要领域， 提议艾滋病毒临床谱的完整描述- 相关疾病也是未来研究的一个重要领域。 这项研究将包括：流行病学，营养和行为 与延长生存期相关的因素， 神经心理学研究，以准确地描述自然历史， 这些疾病在HIV感染中的作用。