Control of pathogenic antibody responses in humans

控制人类致病性抗体反应

• 批准号: nhmrc : GNT1117812
• 负责人: Prof Carola Vinuesa
• 金额: $ 76.38万
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/control-pathogenic-antibody-responses-humans/1347053
• 关键词: Control; pathogenic; antibody; responses; humans

Deficient or inappropriate antibody responses are at the core of many autoimmune diseases, allergies, food intolerances, and often explain the failure of vaccination strategies. Specialised follicular T cells control the quality of antibodies produced by B cells. This fellowship will combine basic studies investigating B cell helper or regulatory follicular T cells in humans with genetic studies identifying the causes of autoantibody-driven diseases. The results will uncover targeted therapies.

抗体反应不足或不适当是许多自身免疫性疾病、过敏、食物不耐受的核心，并且常常是疫苗接种策略失败的原因。专门的滤泡 T 细胞控制 B 细胞产生的抗体的质量。该奖学金将把研究人类 B 细胞辅助细胞或调节性滤泡 T 细胞的基础研究与确定自身抗体驱动疾病原因的遗传学研究结合起来。结果将揭示靶向疗法。