HORMONES, HORMONE RECEPTORS, AND AGING--HORMONE REPLACEMENT IN MENOPAUSAL WOMEN

激素、激素受体和衰老——更年期女性的激素替代

• 批准号: 5200293
• 负责人: S M HARMAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5200293
• 关键词: aging; blood lipid; body composition; bone density; estrogens; female; hormone therapy; human old age (65+); human subject; human therapy evaluation; human tissue; mental health epidemiology; oral administration; postmenopause; progestins; psychometrics; vasomotion

In a study of 30 healthy women 65-75 years of age treated for 2 y with constant combined daily oral estrogen and low dose progestin compared with 30 age-matched female BLSA participants who do not receive ERT, 18 treated subjects completing one year showed significant decreases in depression, anger, and tension as measured by the Profile of Mood Scale (n=18), and significant decreases in vasomotor symptoms. In 16 completing the second year, there were significant increases in total body bone mineral density (3 plum minus 7%), and lumbar spine density (7 plum minus 1%) which correlated with decreases in biomarkers of bone resorption including urinary pyridinoline (30 plus minus 6%) and serum osteocalcin (35 plus minus 6%). There were also significant decreases in total cholesterol (6 plus minus 2%) and LDL cholesterol (14 plus minus 3%)and increases in HDL cholesterol (9 plus minus 4%). Adverse effects included breast swelling and tenderness and vaginal spotting which decreased from a mean of 2.3 plus minus 1.3 days/mo at 3 months to 0.3  .2 days/mo by 1 year. The positive effects on bone, lipids, and affect and minimal adverse effects, suggest that older women should be included in future randomized clinical trials of estrogen use in postmenopausal women. In a longitudinal study of changes in hormone regulation, bone and mineral metabolism, and glucose and lipid metabolism in healthy women during the menopausal transition, 87 women have completed a total of 297 GCRC outpatient visits ranging from 1 to11 visits per individual. Eight women have completed 12 GCRC inpatient visits for 12 hour nocturnal blood sampling. Cross-sectional data analyses comparing the endocrine profiles to the bone biochemistries, bone density measurements, and body composition assessments were begun in August 1995.

在一项对30名年龄在65-75岁的健康女性进行为期2年的治疗的研究中 恒定联合每日口服雌激素与小剂量孕激素的比较 30名年龄匹配的女性BLSA参与者没有接受ERT，18人 完成一年治疗的受试者表现出显著的减少 情绪量表测量的抑郁、愤怒和紧张情绪 (n=18)，血管舒缩症状明显减轻。在16年完成 第二年，全身骨骼显著增加 矿物质密度(3李减7%)和腰椎密度(7李减 1%)，与骨吸收生物标志物的减少相关 包括尿吡啶酚(30加减6%)和血清骨钙素 (35加减6%)。此外，整体数字亦显著下降。 胆固醇(6+负2%)和低密度脂蛋白(14+负3%)以及 高密度脂蛋白胆固醇的增加(9正负4%)。不良反应 包括乳房肿胀和压痛以及阴道斑 从3个月的平均值2.3加负1.3天/月降至0.3 .2天/月，长1年。对骨骼、血脂和情绪的积极影响 和最小的不良反应，建议将老年妇女包括在内 在未来绝经后雌激素使用的随机临床试验中 女人。在一项关于激素调节变化的纵向研究中，骨骼 健康女性的矿物质代谢、糖脂代谢 在更年期过渡期间，87名妇女共完成了297次 GCRC门诊就诊次数从每人1次到11次不等。八 妇女完成了12次GCRC住院治疗，夜间采血12小时 取样。内分泌资料的横断面数据分析比较 骨生物化学、骨密度测量和身体 组成评估于1995年8月开始。