HORMONES, HORMONE RECEPTORS, AND AGING--AGING AND HUMAN ENDOCRINE REGULATION

激素、激素受体与衰老——衰老与人体内分泌调节

• 批准号: 2565629
• 负责人: S M HARMAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2565629
• 关键词: aging; bioenergetics; body composition; cardiovascular disorder epidemiology; clinical research; cortisol; gender difference; growth hormone releasing hormone; hormone regulation /control mechanism; human old age (65+); human subject; human tissue; muscle strength; somatotropin; steroid hormone receptor

In a study of 11 healthy men ages more than 5 y given 2 mg/night of GHRH 1-29 s.c. nightly for 6 weeks measures of phosphocreatine/phosphate ratios and intracellular pH by MRI spectroscopy were consistent with a GHRH treatment effect to reduce the need for anaerobic metabolism during exercise. In a study of GH and sex steroid administration for 6 months, baseline data from 53 healthy women and men more than 65y suggest that there are differing relationships of spontaneous GH and cortisol secretion with one another and with body fat, lean mass, and strength in men vs. women. Thus, (1) GH and cortisol appear to exert gender-specific effects on cardiovascular risk factors, and (2) endogenous cortisol secretion may be related to the declines in strength and mobility which occur in healthy elderly women.

在一项研究中，11名年龄超过5岁的健康男性每晚服用2 mg GHRH 1-29皮下注射连续6周每晚测量磷酸肌酸/磷酸盐 比率和细胞内pH值的MRI光谱是一致的， GHRH治疗效果，以减少无氧代谢的需要， 锻炼的在一项为期6个月的GH和性类固醇给药研究中， 来自53名65岁以上健康女性和男性的基线数据表明， 自发生长激素和皮质醇分泌有不同的关系， 人与人之间的关系，人与人之间的关系。 妇女因此，（1）GH和皮质醇似乎发挥性别特异性的影响 对心血管危险因素，和（2）内源性皮质醇分泌可能 与发生在健康的人身上的力量和流动性的下降有关。 老年妇女。