GENETICS AND PHYSIOLOGY OF VECTOR CAPACITY IN ANOPHELINE MOSQUITOS

目前正在研究按蚊的生物学与 这些媒介传播疟疾的能力。遗传的，分子的， 生化和免疫学研究正在寻求描述机制 在促进或延缓疟疾发展的蚊子中 寄生虫，侧重于卵动生物、卵囊和 子孢子。 为了促进这些研究：1)克隆方法正在改进 以及将基因转置到蚊子生殖系中，以及2)系统正在 评价蚊子胚胎的冷冻保存以增加我们的 储存遗传物质的能力。 识别、克隆和转座调控基因的能力 使蚊子难以抵抗寄生虫发展的机制 应促进根据以下条件制定控制策略 引入蚊子种群领域不能 传播疟疾。

The biology of anopheline mosquitoes is being studied in relation to the capacity of these vectors to transmit malaria. Genetic, molecular, biochemical, and immunological studies are seeking to describe mechanisms in the mosquito that enhance or retard development of the malaria parasite with emphasis on the behavior of ookinetes, oocysts, and sporozoites. To facilitate these studies: 1) methods are being improved for cloning and transposing genes into mosquito germ lines, and 2) systems are being evaluated for the cryopreservation of mosquito embryos to increase our capacity to store genetic material. The ability to identify, clone, and transpose genes that regulate mechanisms that render mosquitoes refractory to parasite development should facilitate development of control strategies based on the introduction into the field of mosquito populations incapable of transmitting malaria.