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IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES

IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES
裂殖子侵入红细胞受体的鉴定
批准号：
3818147
负责人：
L H MILLER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3818147
关键词：
Plasmodium Plasmodium falciparum Plasmodium knowlesi Pongidae cellular immunity communicable disease transmission disease /disorder model erythrocyte membrane erythrocytes human tissue malaria malaria vaccines membrane activity membrane proteins microorganism immunology mutant protozoal antigen receptor surface antigens virulence

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英文摘要
The merozoite interacts in a receptor specific manner with the erythrocyte surface and is the stage against which immunity may work to block invasion. Thus, merozoite surface components are of interest for their role in erythrocyte recognition and as antigens for induction of protective immunity. We are identifying P. knowlesi receptors for attachment to monkey and human erythrocytes and P. falciparum proteins that are involved in the junction between merozoites and erythrocytes. We are studying one antigen on the merozoite surface that undergoes antigenic variation to understand the molecular basis for this variation. We are attempting to adapt P. falciparum to subprimates as an animal model for vaccine trials.
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IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES
IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES
IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES
IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES
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