GENETICS AND PHYSIOLOGY OF VECTOR CAPACITY IN ANOPHELINE MOSQUITOS

目前正在研究按蚊的生物学与 这些媒介传播疟疾的能力。遗传的，分子的， 生化和免疫学研究正在寻求描述机制 在促进或延缓疟疾发展的蚊子中 寄生虫，侧重于卵动生物、卵囊和 子孢子。 为了促进这些研究1)技术已经发展到 培养疟疾寄生虫的孢子期(蚊子)阶段 体外；2)基因克隆和转座的方法正在改进 进入蚊子生殖系；3)正在评估这些系统 冷冻保存蚊子胚胎以增加我们的储存能力 遗传物质。 识别、克隆和转座调控基因的能力 蚊子对寄生虫发展产生抵抗力的机制 应促进根据以下条件制定控制策略 引入蚊子种群领域不能 传播疟疾。

The biology of anopheline mosquitoes is being studied in relation to the capacity of these vectors to transmit malaria. Genetic, molecular, biochemical and immunological studies are seeking to describe mechanisms in the mosquito which enhance or retard development of the malaria parasite with emphasis on the behavior of ookinetes, oocysts and sporozoites. To facilitate these studies 1) techniques have been developed to cultivate the sporogonic (mosquito) stages of the malaria parasite in vitro; 2) methods are being improved for cloning and transposing genes into mosquito germ lines; 3) systems are being evaluated for the cryopreservation of mosquito embryos to increase our capacity to store genetic material. The ability to identify, clone, and transpose genes which regulate mechanisms which render mosquitoes refractory to parasite development should facilitate development of control strategies based on the introduction into the field of mosquito populations incapable of transmitting malaria.