GENETICS AND PHYSIOLOGY OF VECTOR CAPACITY IN ANOPHELINE MOSQUITOS

蚊子和疟疾寄生虫的生物学正在研究中， 了解疟疾通过昆虫传播的分子基础。 分子、生物化学和免疫学方法用于研究 蚊子体内寄生虫的发展，并确定关键的蚊子， 影响疟疾传播的寄生虫分子。 为了促进这些研究，我们集中在1）动合子如何出口 2）动合子如何粘附和侵入蚊子中肠 上皮，3）卵囊发育如何发生和4）受体是什么 子孢子侵入蚊子唾液腺。 我们还在开发从基因上改变 蚊子传播疟疾和长期储存疟疾病媒 用于基因研究的胚胎。

The biology of mosquitoes and malaria parasites are being studied to understand the molecular basis of malaria transmission by insect vectors. Molecular, biochemical, and immunological methods are used to study parasite development in mosquito and identify crucial mosquito and parasite molecules that influence malaria transmission. To facilitate these studies we have focused on 1) how ookinete egress from the blood meal, 2) how ookinete adhere and invade mosquito midgut epithelium, 3) how oocyst development occur and 4) what is the receptor for sporozoite invasion of mosquito salivary glands. We are also developing methods to genetically alter the ability of mosquitoes to transmit malaria and long term storage of malaria vector embryos for genetic research.