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GENETICS AND PHYSIOLOGY OF VECTOR CAPACITY IN ANOPHELINE MOSQUITOS

GENETICS AND PHYSIOLOGY OF VECTOR CAPACITY IN ANOPHELINE MOSQUITOS
按蚊载体能力的遗传学和生理学
批准号：
2566725
负责人：
L H MILLER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/2566725
关键词：
Culicidae animal population genetics arthropod genetics communicable disease transmission disease vectors genetic manipulation genetically modified animals host organism interaction larva life cycle malaria microorganism genetics microorganism growth microorganism immunology

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英文摘要
The biology of mosquitoes and malaria parasites are being studied to understand the molecular basis of malaria transmission by insect vectors. Molecular, biochemical, and immunological methods are used to study parasite development in mosquito and identify crucial mosquito and parasite molecules that influence malaria transmission. To facilitate these studies we have focused on 1) how ookinete egress from the blood meal, 2) how ookinete adhere and invade mosquito midgut epithelium, 3) how oocyst development occur and 4) what is the receptor for sporozoite invasion of mosquito salivary glands. We are also developing methods to genetically alter the ability of mosquitoes to transmit malaria and long term storage of malaria vector embryos for genetic research.
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