GENETICS AND PHYSIOLOGY OF VECTOR CAPACITY IN ANOPHELINE MOSQUITOS

蚊子和疟疾寄生虫的生物学正在研究中 了解通过昆虫媒介传播疟疾的分子基础。 分子、生物化学和免疫学方法用于研究 寄生虫在蚊子中的发展，并识别关键蚊子和 影响疟疾传播的寄生虫分子。 为了促进这些研究，我们将重点放在1)运动如何出口 从血粉，2)动植物如何附着和入侵蚊子中肠 上皮细胞，3)卵囊如何发生和4)什么是受体 用于子孢子侵入蚊子唾液腺。 我们还在开发从基因上改变人的能力的方法 蚊子传播疟疾与疟疾媒介的长期保存 用于基因研究的胚胎。

The biology of mosquitoes and malaria parasites are being studied to understand the molecular basis of malaria transmission by insect vectors. Molecular, biochemical, and immunological methods are used to study parasite development in mosquito and identify crucial mosquito and parasite molecules that influence malaria transmission. To facilitate these studies we have focused on 1) how ookinete egress from the blood meal, 2) how ookinete adhere and invade mosquito midgut epithelium, 3) how oocyst development occur and 4) what is the receptor for sporozoite invasion of mosquito salivary glands. We are also developing methods to genetically alter the ability of mosquitoes to transmit malaria and long term storage of malaria vector embryos for genetic research.