NMR relaxometry for biomedicine and advanced materials: FC-RELAX

用于生物医学和先进材料的 NMR 弛豫测量：FC-RELAX

• 批准号: EP/X032248/1
• 负责人: Lionel Broche
• 金额: $ 33.8万
• 依托单位: University of Aberdeen
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FX032248%2F1
• 关键词: NMR; relaxometry; biomedicine; advanced; materials

This project aims to better exploit the role of Field-cycling (FC) relaxometry in biology, medicine and innovative materials by extending the breadth of molecular dynamics models that are available as a tool for the users. The modelling themes included here focus on specific challenges to which Fast FC relaxometry can provide major contributions, namely MRI contrast agents, medical diagnosis and batteries/supercapacitors. This cross-disciplinary approach stimulates strong interconnections between the theme leaders to explore domains ranging from nanosystems for medical applications to the imaging of cancer, and from the development of spin relaxation theories to the description of dynamics of biomolecules. For instance, the investigation of the relaxometry profiles of complex systems, as for instance nanogels, nanoparticles and nanomaterials with multiple water pools, will allow for the characterization of their mobility and for the evaluation of the exchange rate of water molecules from one pool to another, thus paving the way for improving their efficiency as diagnostic, pharmaceutical and medical devices.

该项目旨在通过扩展分子动力学模型的广度，更好地发挥场循环(FC)弛豫计量学在生物学、医学和创新材料中的作用，这些模型可作为用户的工具。这里包含的建模主题集中于Fast FC弛豫测量可以做出重大贡献的具体挑战，即MRI造影剂、医疗诊断和电池/超级电容器。这种跨学科的方法刺激了主题领导者之间的强有力的相互联系，以探索从医学应用的纳米系统到癌症成像的领域，以及从自旋松弛理论的发展到生物分子动力学的描述。例如，对复杂体系，如纳米凝胶、纳米颗粒和具有多个水池的纳米材料的弛豫曲线的研究，将能够表征它们的流动性，并评估水分子从一个水池到另一个水池的交换率，从而为提高它们作为诊断、制药和医疗设备的效率铺平道路。