ALTERATIONS OF INSULIN SECRETION IN GENETIC FORMS OF NIDDM

NIDDM 基因形式中胰岛素分泌的改变

• 批准号: 3740368
• 负责人: KENNETH S POLONSKY
• 金额: --
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3740368
• 关键词: diabetes mellitus genetics; fasting; gene mutation; genetic markers; glucokinase; glucose; glucose tolerance test; hormone regulation /control mechanism; human subject; insulin; noninsulin dependent diabetes mellitus; obesity; pancreatic islet function

We will explore the dose response relationships between glucose and insulin secretion rates in normal individuals, obese subjects with normal GTT, and patients with various forms of NIDDM including patients who have been demonstrated to have mutations in the glucokinase gene or who are positive for the marker for diabetes present on chromosome 20. The effects of glucose infusion and fasting on the glucose insulin secretion rate dose response curve will be studied.

我们将探讨葡萄糖和胰岛素之间的剂量反应关系。 正常人、肥胖者和正常人的胰岛素分泌率 GTT和各种形式的NIDDM患者，包括患有 已被证明具有葡萄糖激酶基因突变或患有 对20号染色体上的糖尿病标记呈阳性。 的 葡萄糖输注和禁食对葡萄糖胰岛素分泌的影响 将研究速率剂量反应曲线。