Controlling the pro-survival protein Mcl-1: discovering novel opportunities and developing innovative approaches to target Mcl-1 for treating cancers

控制促生存蛋白 Mcl-1：发现新机会并开发针对 Mcl-1 治疗癌症的创新方法

• 批准号: nhmrc : 1057742
• 负责人: A/Pr Christopher Burns
• 金额: $ 49.97万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/controlling-pro-survival-treating-cancers/454627
• 关键词: Controlling; pro; survival; protein; Mcl

Cancer cells are often sustained by evading cell death. Thus, a promising approach to develop new cancer treatments aims to restore their ability to commit cell suicide. Proteins related to Bcl-2 are, in this regard, attractive targets because they are prominent barriers to cell death. This project seeks to uncover how a Bcl-2 relative, Mcl-1, is regulated, and to explore how the mechanisms that underpin these processes can be targeted in cancers (melanomas, leukemias) that it sustains.

癌细胞通常是通过逃避细胞死亡来维持的。因此，一种有希望的方法来开发新的癌症治疗方法，旨在恢复他们自杀细胞的能力。在这方面，与Bcl-2相关的蛋白质是有吸引力的靶标，因为它们是细胞死亡的显著障碍。该项目旨在揭示Bcl2相关基因Mcl-1是如何被调控的，并探索支撑这些过程的机制如何在其所持续的癌症(黑色素瘤、白血病)中被靶向。