Alternative targets for treating cancer

癌细胞通常是通过逃避细胞死亡而存活下来的。因此，开发新的癌症治疗方法的一个很有希望的方法是恢复它们进行细胞自杀的能力。在这方面，与Bcl-2相关的蛋白质是有吸引力的靶标，因为它们是细胞死亡的重要屏障。该项目旨在揭示Bcl-2的近亲Mcl-1是如何被调节的，并探索支撑这些过程的机制如何能够靶向它所维持的癌症（黑色素瘤、白血病）。

Cancer cells are often sustained by evading cell death. Thus, a promising approach to develop new cancer treatments aims to restore their ability to commit cell suicide. Proteins related to Bcl-2 are, in this regard, attractive targets because they are prominent barriers to cell death. This project seeks to uncover how a Bcl-2 relative, Mcl-1, is regulated, and to explore how the mechanisms that underpin these processes can be targeted in cancers (melanomas, leukemias) that it sustains.