Understanding ligand binding within the insulin-like growth factor family with direct application to cancer therapeutic design

了解胰岛素样生长因子家族中的配体结合并直接应用于癌症治疗设计

• 批准号: nhmrc : 1128553
• 负责人: A/Pr Christopher Burns
• 金额: $ 58.78万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-ligand-binding-therapeutic-design/948241
• 关键词: Understanding; ligand; binding; within; insulin

Cancer is a devastating disease and there is an imperative to develop new therapeutics. The so-called insulin-like growth factors are molecules that play a key role in the initiation and progression of cancer. Here we seek to understand how these molecules interact with cells and to develop drugs that might block their action.

癌症是一种毁灭性的疾病，必须开发新的治疗方法。所谓的胰岛素样生长因子是在癌症的发生和发展中起关键作用的分子。在这里，我们试图了解这些分子如何与细胞相互作用，并开发可能阻止其作用的药物。