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INTERACTION BETWEEN SPINAL NEOSTIGMINE AND INTRAVENOUS ALFENTANIL

INTERACTION BETWEEN SPINAL NEOSTIGMINE AND INTRAVENOUS ALFENTANIL
脊髓新斯的明和静脉注射阿芬太尼之间的相互作用
批准号：
3744961
负责人：
James Eisenach
金额：
$0.0万
依托单位：
WAKE FOREST UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3744961
关键词：
acetylcholine adrenergic receptor anesthetics drug interactions endogenous opioid human subject intravenous administration neostigmine norepinephrine pharmacokinetics

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Systematically administered opioids activate bulbospinal noradrenergic pathways. The resulting spinally released norepinephrine activates a 2-adrenoceptors on cholinergic neurons, causing ACh release and inhibition of spinal transmission of noxious sensory information. This study investigates the interaction between i.t. neostigmine and intravenous alfentanil in potentiating analygesia from intraspinal a-adrenergic agonist and from systemic opioids.
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